eF-site ID 4cbo_55-AB
PDB Code 4cbo
Model 55
Chain A, B

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Title Crystal structure of Complement Factor D mutant R202A after ensemble refinement
Classification HYDROLASE
Compound COMPLEMENT FACTOR D
Source Homo sapiens (Human) (CFAD_HUMAN)
Sequence A:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA
HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD
SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG
TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH
DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG
SAVCGNRKKPGIYTRVASYAAWIDSVLA
B:  ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAA
HCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPD
SQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPG
TLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHH
DGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG
SAVCGNRKKPGIYTRVASYAAWIDSVLA
Description


Functional site

1) chain A
residue 117
type
sequence V
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

2) chain A
residue 119
type
sequence P
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

3) chain A
residue 148
type
sequence V
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

4) chain A
residue 149
type
sequence L
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

5) chain A
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

6) chain A
residue 151
type
sequence R
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

7) chain A
residue 169
type
sequence M
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

8) chain A
residue 170
type
sequence C
description BINDING SITE FOR RESIDUE GOL A 1000
source : AC1

9) chain B
residue 117
type
sequence V
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

10) chain B
residue 119
type
sequence P
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

11) chain B
residue 148
type
sequence V
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

12) chain B
residue 149
type
sequence L
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

13) chain B
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

14) chain B
residue 151
type
sequence R
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

15) chain B
residue 169
type
sequence M
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

16) chain B
residue 170
type
sequence C
description BINDING SITE FOR RESIDUE GOL B 1000
source : AC2

17) chain A
residue 41
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 89
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 183
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 41
type ACT_SITE
sequence H
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

21) chain B
residue 89
type ACT_SITE
sequence D
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

22) chain B
residue 183
type ACT_SITE
sequence S
description Charge relay system
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 37-42
type prosite
sequence LSAAHC
description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
source prosite : PS00134

24) chain A
residue 177-188
type prosite
sequence DSCKGDSGGPLV
description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
source prosite : PS00135


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