eF-site ID 4ca1-A PDB Code 4ca1 Chain A click to enlarge Title Crystal structure of Siah1 at 1.58 A resolution. Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE SIAH1 Source Homo sapiens (Human) (SIAH1_HUMAN) Sequence A:  ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPC PGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDI NLPGAVDWVMMQSCFGFHFMLVLEKQEKHQQFFAIVQLIG TRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMN SDCLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain A residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 2) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 3) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 4) chain A residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 5) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 6) chain A residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 7) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 8) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 9) chain A residue 124 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1283 source : AC5 10) chain A residue 126 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1283 source : AC5 11) chain A residue 214 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1283 source : AC5 12) chain A residue 215 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1283 source : AC5 13) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1284 source : AC6 14) chain A residue 151 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1285 source : AC9 15) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1285 source : AC9 16) chain A residue 153 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1285 source : AC9 17) chain A residue 154 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1285 source : AC9 18) chain A residue 232 type sequence R description BINDING SITE FOR RESIDUE CL A 1286 source : BC3 19) chain A residue 246 type sequence G description BINDING SITE FOR RESIDUE GOL A 1287 source : BC5 20) chain A residue 247 type sequence I description BINDING SITE FOR RESIDUE GOL A 1287 source : BC5 21) chain A residue 248 type sequence A description BINDING SITE FOR RESIDUE GOL A 1287 source : BC5 22) chain A residue 228 type sequence N description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 23) chain A residue 229 type sequence G description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 24) chain A residue 230 type sequence H description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 25) chain A residue 266 type sequence L description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 26) chain A residue 267 type sequence F description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 27) chain A residue 268 type sequence A description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 28) chain A residue 269 type sequence E description BINDING SITE FOR RESIDUE GOL A 1288 source : BC6 29) chain A residue 231 type sequence R description BINDING SITE FOR RESIDUE GOL A 1289 source : BC9 30) chain A residue 224 type sequence R description BINDING SITE FOR RESIDUE GOL A 1290 source : CC4 31) chain A residue 161 type sequence E description BINDING SITE FOR RESIDUE GOL A 1291 source : CC5 32) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE GOL A 1291 source : CC5 33) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE GOL A 1291 source : CC5 34) chain A residue 187 type sequence F description BINDING SITE FOR RESIDUE GOL A 1291 source : CC5 35) chain A residue 168 type sequence T description BINDING SITE FOR RESIDUE GOL A 1292 source : CC6 36) chain A residue 176 type sequence V description BINDING SITE FOR RESIDUE GOL A 1292 source : CC6 37) chain A residue 177 type sequence D description BINDING SITE FOR RESIDUE GOL A 1292 source : CC6 38) chain A residue 178 type sequence W description BINDING SITE FOR RESIDUE GOL A 1292 source : CC6 39) chain A residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 41) chain A residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 42) chain A residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 43) chain A residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 44) chain A residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 45) chain A residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 46) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 47) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3

Display surface Download Links