eF-site ID 4c9z-AB PDB Code 4c9z Chain A, B click to enlarge Title Crystal structure of Siah1 at 1.95 A resolution Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE SIAH1 Source Homo sapiens (Human) (SIAH1_HUMAN) Sequence A:  MANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCP CPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATD INLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIV QLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIAT AIMNSDCLVFDTSIAQLFAENGNLGINVTISMC B:  LFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGAS CKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPG AVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGT RKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNS DCLVFDTSIAQLFAENGNLGINVTISMC Description Functional site 1) chain A residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 2) chain A residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 3) chain A residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 4) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN A 283 source : AC1 5) chain A residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 6) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 7) chain A residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 8) chain A residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN A 284 source : AC2 9) chain B residue 128 type sequence C description BINDING SITE FOR RESIDUE ZN B 283 source : AC3 10) chain B residue 135 type sequence C description BINDING SITE FOR RESIDUE ZN B 283 source : AC3 11) chain B residue 147 type sequence H description BINDING SITE FOR RESIDUE ZN B 283 source : AC3 12) chain B residue 152 type sequence H description BINDING SITE FOR RESIDUE ZN B 283 source : AC3 13) chain B residue 98 type sequence C description BINDING SITE FOR RESIDUE ZN B 284 source : AC4 14) chain B residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN B 284 source : AC4 15) chain B residue 117 type sequence H description BINDING SITE FOR RESIDUE ZN B 284 source : AC4 16) chain B residue 121 type sequence C description BINDING SITE FOR RESIDUE ZN B 284 source : AC4 17) chain A residue 224 type sequence R description BINDING SITE FOR RESIDUE CL A 1283 source : AC5 18) chain B residue 224 type sequence R description BINDING SITE FOR RESIDUE CL B 1286 source : AC6 19) chain A residue 230 type sequence H description BINDING SITE FOR RESIDUE CL A 1285 source : AC7 20) chain A residue 232 type sequence R description BINDING SITE FOR RESIDUE CL A 1285 source : AC7 21) chain A residue 237 type sequence E description BINDING SITE FOR RESIDUE TRS B 1283 source : AC8 22) chain A residue 238 type sequence A description BINDING SITE FOR RESIDUE TRS B 1283 source : AC8 23) chain B residue 231 type sequence R description BINDING SITE FOR RESIDUE TRS B 1283 source : AC8 24) chain B residue 232 type sequence R description BINDING SITE FOR RESIDUE TRS B 1283 source : AC8 25) chain B residue 233 type sequence R description BINDING SITE FOR RESIDUE TRS B 1283 source : AC8 26) chain A residue 231 type sequence R description BINDING SITE FOR RESIDUE GOL A 1286 source : AC9 27) chain A residue 232 type sequence R description BINDING SITE FOR RESIDUE GOL A 1286 source : AC9 28) chain A residue 233 type sequence R description BINDING SITE FOR RESIDUE GOL A 1286 source : AC9 29) chain B residue 222 type sequence A description BINDING SITE FOR RESIDUE GOL A 1286 source : AC9 30) chain A residue 161 type sequence E description BINDING SITE FOR RESIDUE GOL A 1287 source : BC1 31) chain A residue 184 type sequence C description BINDING SITE FOR RESIDUE GOL A 1287 source : BC1 32) chain A residue 185 type sequence F description BINDING SITE FOR RESIDUE GOL A 1287 source : BC1 33) chain A residue 186 type sequence G description BINDING SITE FOR RESIDUE GOL A 1287 source : BC1 34) chain A residue 187 type sequence F description BINDING SITE FOR RESIDUE GOL A 1287 source : BC1 35) chain A residue 239 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1284 source : BC2 36) chain A residue 241 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1284 source : BC2 37) chain B residue 231 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1284 source : BC2 38) chain B residue 232 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1284 source : BC2 39) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1285 source : BC3 40) chain B residue 146 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1285 source : BC3 41) chain B residue 147 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1285 source : BC3 42) chain B residue 150 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1285 source : BC3 43) chain B residue 151 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1285 source : BC3 44) chain A residue 130 type sequence C description BINDING SITE FOR RESIDUE GOL A 1288 source : BC4 45) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE GOL A 1288 source : BC4 46) chain A residue 153 type sequence K description BINDING SITE FOR RESIDUE GOL A 1288 source : BC4 47) chain A residue 154 type sequence S description BINDING SITE FOR RESIDUE GOL A 1288 source : BC4 48) chain A residue 119 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1289 source : BC5 49) chain A residue 124 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1289 source : BC5 50) chain A residue 214 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1289 source : BC5 51) chain A residue 215 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1289 source : BC5 52) chain A residue 244 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1289 source : BC5 53) chain A residue 219 type sequence E description BINDING SITE FOR RESIDUE TRS A 1290 source : BC6 54) chain A residue 220 type sequence N description BINDING SITE FOR RESIDUE TRS A 1290 source : BC6 55) chain A residue 282 type sequence C description BINDING SITE FOR RESIDUE TRS A 1290 source : BC6 56) chain A residue 282 type sequence C description BINDING SITE FOR RESIDUE TRS A 1290 source : BC6 57) chain A residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 58) chain A residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 59) chain A residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 60) chain A residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 61) chain B residue 98 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 62) chain B residue 105 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 63) chain B residue 117 type BINDING sequence H description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 64) chain B residue 121 type BINDING sequence C description BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI2 65) chain A residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 66) chain A residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 67) chain A residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 68) chain A residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 69) chain B residue 128 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 70) chain B residue 135 type BINDING sequence C description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 71) chain B residue 147 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 72) chain B residue 152 type BINDING sequence H description BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ source Swiss-Prot : SWS_FT_FI3 73) chain A residue 93-153 type ZN_FING sequence SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPG ASCKWQGSLDAVMPHLMHQHK description SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 source Swiss-Prot : SWS_FT_FI1

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