eF-site ID 4c6y-AB PDB Code 4c6y Chain A, B click to enlarge Title Ancestral PNCA (last common ancestors of Gram-positive and Gram- negative bacteria) beta-lactamase class A Classification HYDROLASE Compound BETA-LACTAMASE Source (4C6Y) Sequence A:  AAALSEQLAELEKRSGGRLGVAVLDTATGRRIAYRGDERF PMCSTFKALLAAAVLAQVDQGKERLDRRITYSKADLVDYS PVTEKHVGGGMTVAELCEAAITYSDNTAANLLLEALGGPA ALTAFLRSIGDEVTRLDRWEPELNEALPGDPRDTTTPRAM AATLRKLLLGDALSPASREQLVDWLLANKTGDKRLRAGLP ADWRVGDKTGTGGHGTTNDIAVIWPPNRAPIVVAVYYTES QADAEARDAVIAEVGRLVAEAF B:  AALSEQLAELEKRSGGRLGVAVLDTATGRRIAYRGDERFP MCSTFKALLAAAVLAQVDQGKERLDRRITYSKADLVDYSP VTEKHVGGGMTVAELCEAAITYSDNTAANLLLEALGGPAA LTAFLRSIGDEVTRLDRWEPELNEALPGDPRDTTTPRAMA ATLRKLLLGDALSPASREQLVDWLLANKTGDKRLRAGLPA DWRVGDKTGTGGHGTTNDIAVIWPPNRAPIVVAVYYTESQ ADAEARDAVIAEVGRLVAEAF Description Functional site 1) chain A residue 83 type sequence Q description BINDING SITE FOR RESIDUE PG4 A 291 source : AC1 2) chain A residue 86 type sequence Q description BINDING SITE FOR RESIDUE PG4 A 291 source : AC1 3) chain A residue 88 type sequence K description BINDING SITE FOR RESIDUE PG4 A 291 source : AC1 4) chain A residue 151 type sequence F description BINDING SITE FOR RESIDUE PG4 A 291 source : AC1 5) chain A residue 215 type sequence K description BINDING SITE FOR RESIDUE PG4 A 291 source : AC1 6) chain A residue 163 type sequence D description BINDING SITE FOR RESIDUE PEG A 292 source : AC2 7) chain A residue 205 type sequence E description BINDING SITE FOR RESIDUE PEG A 292 source : AC2 8) chain A residue 206 type sequence Q description BINDING SITE FOR RESIDUE PEG A 292 source : AC2 9) chain A residue 204 type sequence R description BINDING SITE FOR RESIDUE NA A 293 source : AC3 10) chain A residue 272 type sequence A description BINDING SITE FOR RESIDUE NA A 293 source : AC3 11) chain A residue 273 type sequence E description BINDING SITE FOR RESIDUE NA A 293 source : AC3 12) chain A residue 155 type sequence I description BINDING SITE FOR RESIDUE PEG A 294 source : AC4 13) chain A residue 157 type sequence D description BINDING SITE FOR RESIDUE PEG A 294 source : AC4 14) chain A residue 185 type sequence A description BINDING SITE FOR RESIDUE PEG A 294 source : AC4 15) chain A residue 188 type sequence A description BINDING SITE FOR RESIDUE PEG A 294 source : AC4 16) chain A residue 189 type sequence T description BINDING SITE FOR RESIDUE PEG A 294 source : AC4 17) chain A residue 107 type sequence P description BINDING SITE FOR RESIDUE PEG A 295 source : AC5 18) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE PEG A 295 source : AC5 19) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE ACT A 296 source : AC6 20) chain A residue 225 type sequence L description BINDING SITE FOR RESIDUE ACT A 296 source : AC6 21) chain A residue 226 type sequence P description BINDING SITE FOR RESIDUE ACT A 296 source : AC6 22) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE ACT A 296 source : AC6 23) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE PEG A 297 source : AC7 24) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE PEG A 297 source : AC7 25) chain A residue 281 type sequence E description BINDING SITE FOR RESIDUE PEG A 297 source : AC7 26) chain A residue 274 type sequence A description BINDING SITE FOR RESIDUE PEG A 298 source : AC8 27) chain A residue 43 type sequence R description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 28) chain A residue 65 type sequence R description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 29) chain A residue 174 type sequence P description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 30) chain A residue 175 type sequence G description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 31) chain A residue 176 type sequence D description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 32) chain A residue 177 type sequence P description BINDING SITE FOR RESIDUE PEG A 299 source : AC9 33) chain A residue 154 type sequence S description BINDING SITE FOR RESIDUE PEG A 300 source : BC1 34) chain A residue 192 type sequence K description BINDING SITE FOR RESIDUE PEG A 300 source : BC1 35) chain A residue 269 type sequence Q description BINDING SITE FOR RESIDUE PEG A 300 source : BC1 36) chain A residue 56 type sequence R description BINDING SITE FOR RESIDUE PEG A 301 source : BC2 37) chain A residue 57 type sequence I description BINDING SITE FOR RESIDUE PEG A 301 source : BC2 38) chain A residue 58 type sequence A description BINDING SITE FOR RESIDUE PEG A 301 source : BC2 39) chain A residue 184 type sequence R description BINDING SITE FOR RESIDUE PEG A 301 source : BC2 40) chain A residue 87 type sequence G description BINDING SITE FOR RESIDUE PEG A 302 source : BC3 41) chain A residue 90 type sequence R description BINDING SITE FOR RESIDUE PEG A 302 source : BC3 42) chain A residue 93 type sequence R description BINDING SITE FOR RESIDUE PEG A 302 source : BC3 43) chain A residue 94 type sequence R description BINDING SITE FOR RESIDUE PEG A 303 source : BC4 44) chain A residue 116 type sequence G description BINDING SITE FOR RESIDUE PEG A 303 source : BC4 45) chain A residue 121 type sequence E description BINDING SITE FOR RESIDUE PEG A 303 source : BC4 46) chain B residue 31 type sequence E description BINDING SITE FOR RESIDUE PEG A 303 source : BC4 47) chain B residue 35 type sequence E description BINDING SITE FOR RESIDUE PEG A 303 source : BC4 48) chain A residue 93 type sequence R description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 49) chain A residue 95 type sequence I description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 50) chain A residue 137 type sequence L description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 51) chain A residue 141 type sequence A description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 52) chain A residue 227 type sequence A description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 53) chain A residue 230 type sequence R description BINDING SITE FOR RESIDUE PEG A 304 source : BC5 54) chain A residue 219 type sequence K description BINDING SITE FOR RESIDUE PEG A 305 source : BC6 55) chain A residue 167 type sequence P description BINDING SITE FOR RESIDUE GOL A 306 source : BC7 56) chain A residue 70 type sequence S description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 57) chain A residue 130 type sequence S description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 58) chain A residue 132 type sequence N description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 59) chain A residue 235 type sequence T description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 60) chain A residue 236 type sequence G description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 61) chain A residue 237 type sequence T description BINDING SITE FOR RESIDUE PEG A 307 source : BC8 62) chain A residue 56 type sequence R description BINDING SITE FOR RESIDUE NA A 308 source : BC9 63) chain A residue 184 type sequence R description BINDING SITE FOR RESIDUE NA A 308 source : BC9 64) chain B residue 48 type sequence V description BINDING SITE FOR RESIDUE PEG B 291 source : CC1 65) chain B residue 56 type sequence R description BINDING SITE FOR RESIDUE PEG B 291 source : CC1 66) chain B residue 57 type sequence I description BINDING SITE FOR RESIDUE PEG B 291 source : CC1 67) chain B residue 184 type sequence R description BINDING SITE FOR RESIDUE PEG B 291 source : CC1 68) chain B residue 188 type sequence A description BINDING SITE FOR RESIDUE PEG B 291 source : CC1 69) chain A residue 257 type sequence A description BINDING SITE FOR RESIDUE CL B 292 source : CC2 70) chain B residue 65 type sequence R description BINDING SITE FOR RESIDUE CL B 292 source : CC2 71) chain B residue 70 type sequence S description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 72) chain B residue 105 type sequence Y description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 73) chain B residue 130 type sequence S description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 74) chain B residue 132 type sequence N description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 75) chain B residue 235 type sequence T description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 76) chain B residue 236 type sequence G description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 77) chain B residue 237 type sequence T description BINDING SITE FOR RESIDUE PEG B 293 source : CC3 78) chain B residue 140 type sequence E description BINDING SITE FOR RESIDUE PEG B 294 source : CC4 79) chain B residue 165 type sequence W description BINDING SITE FOR RESIDUE PEG B 294 source : CC4 80) chain B residue 163 type sequence D description BINDING SITE FOR RESIDUE PEG B 295 source : CC5 81) chain B residue 164 type sequence R description BINDING SITE FOR RESIDUE PEG B 295 source : CC5 82) chain B residue 165 type sequence W description BINDING SITE FOR RESIDUE PEG B 295 source : CC5 83) chain B residue 168 type sequence E description BINDING SITE FOR RESIDUE PEG B 295 source : CC5 84) chain B residue 212 type sequence L description BINDING SITE FOR RESIDUE PEG B 296 source : CC6 85) chain B residue 214 type sequence N description BINDING SITE FOR RESIDUE PEG B 296 source : CC6 86) chain B residue 215 type sequence K description BINDING SITE FOR RESIDUE PEG B 296 source : CC6 87) chain B residue 218 type sequence D description BINDING SITE FOR RESIDUE PEG B 296 source : CC6 88) chain A residue 111 type sequence K description BINDING SITE FOR RESIDUE PEG B 297 source : CC7 89) chain A residue 112 type sequence H description BINDING SITE FOR RESIDUE PEG B 297 source : CC7 90) chain B residue 38 type sequence K description BINDING SITE FOR RESIDUE PEG B 297 source : CC7 91) chain B residue 142 type sequence L description BINDING SITE FOR RESIDUE PEG B 298 source : CC8 92) chain B residue 147 type sequence A description BINDING SITE FOR RESIDUE PEG B 298 source : CC8 93) chain B residue 154 type sequence S description BINDING SITE FOR RESIDUE PEG B 298 source : CC8 94) chain B residue 85 type sequence D description BINDING SITE FOR RESIDUE PEG B 299 source : CC9 95) chain B residue 111 type sequence K description BINDING SITE FOR RESIDUE PEG B 299 source : CC9 96) chain B residue 203 type sequence S description BINDING SITE FOR RESIDUE PEG B 299 source : CC9 97) chain B residue 206 type sequence Q description BINDING SITE FOR RESIDUE PEG B 299 source : CC9 98) chain A residue 53 type sequence T description BINDING SITE FOR RESIDUE ACT B 300 source : DC1 99) chain A residue 55 type sequence R description BINDING SITE FOR RESIDUE ACT B 300 source : DC1 100) chain B residue 161 type sequence R description BINDING SITE FOR RESIDUE ACT B 300 source : DC1 101) chain B residue 219 type sequence K description BINDING SITE FOR RESIDUE PG4 B 301 source : DC2 102) chain A residue 66-81 type prosite sequence FPMCSTFKALLAAAVL description BETA_LACTAMASE_A Beta-lactamase class-A active site. FpMCSTfKallAAAVL source prosite : PS00146

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