eF-site ID 4c6n-A PDB Code 4c6n Chain A click to enlarge Title Crystal structure of the dihydroorotase domain of human CAD E1637T mutant bound to substrate at pH 6.0 Classification HYDROLASE Compound CAD PROTEIN Source Homo sapiens (Human) (PYR1_HUMAN) Sequence A:  LVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMV CAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSE NAGTLGTVAGSAAGLXLYLNETFSELRLDSVVQWMEHFET WPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEE ILLIKAAKARGLPVTCTVAPHHLFLSHDDLERLGPGKGEV RPELGSRQDVEALWENMAVIDCFASDHAPHTLEEKCGSRP PPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIF HLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVK GTVRRVVLRGEVAYIDGQVLVPPGYGQDVRKWPQGAVPQL PPS Description Functional site 1) chain A residue 1556 type sequence X description BINDING SITE FOR RESIDUE ZN A 2824 source : AC1 2) chain A residue 1590 type sequence H description BINDING SITE FOR RESIDUE ZN A 2824 source : AC1 3) chain A residue 1614 type sequence H description BINDING SITE FOR RESIDUE ZN A 2824 source : AC1 4) chain A residue 1471 type sequence H description BINDING SITE FOR RESIDUE ZN A 2825 source : AC2 5) chain A residue 1473 type sequence H description BINDING SITE FOR RESIDUE ZN A 2825 source : AC2 6) chain A residue 1556 type sequence X description BINDING SITE FOR RESIDUE ZN A 2825 source : AC2 7) chain A residue 1686 type sequence D description BINDING SITE FOR RESIDUE ZN A 2825 source : AC2 8) chain A residue 1586 type sequence P description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 9) chain A residue 1587 type sequence I description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 10) chain A residue 1608 type sequence R description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 11) chain A residue 1609 type sequence S description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 12) chain A residue 1610 type sequence V description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 13) chain A residue 1611 type sequence H description BINDING SITE FOR RESIDUE FMT A 2826 source : AC3 14) chain A residue 1471 type sequence H description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 15) chain A residue 1473 type sequence H description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 16) chain A residue 1475 type sequence R description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 17) chain A residue 1505 type sequence N description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 18) chain A residue 1556 type sequence X description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 19) chain A residue 1562 type sequence T description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 20) chain A residue 1563 type sequence F description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 21) chain A residue 1590 type sequence H description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 22) chain A residue 1614 type sequence H description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 23) chain A residue 1660 type sequence V description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 24) chain A residue 1661 type sequence R description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 25) chain A residue 1686 type sequence D description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 26) chain A residue 1688 type sequence A description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 27) chain A residue 1690 type sequence H description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 28) chain A residue 1702 type sequence P description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 29) chain A residue 1703 type sequence G description BINDING SITE FOR RESIDUE NCD A 2827 source : AC4 30) chain A residue 1734 type sequence H description BINDING SITE FOR RESIDUE FMT A 2828 source : AC5 31) chain A residue 1734 type sequence H description BINDING SITE FOR RESIDUE FMT A 2828 source : AC5 32) chain A residue 1737 type sequence R description BINDING SITE FOR RESIDUE FMT A 2828 source : AC5 33) chain A residue 1737 type sequence R description BINDING SITE FOR RESIDUE FMT A 2828 source : AC5 34) chain A residue 1470 type sequence V description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 35) chain A residue 1471 type sequence H description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 36) chain A residue 1503 type sequence M description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 37) chain A residue 1611 type sequence H description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 38) chain A residue 1613 type sequence C description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 39) chain A residue 1637 type sequence T description BINDING SITE FOR RESIDUE FMT A 2829 source : AC6 40) chain A residue 1469-1477 type prosite sequence DVHVHLREP description DIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP source prosite : PS00482 41) chain A residue 1684-1695 type prosite sequence ASDHAPHTLEEK description DIHYDROOROTASE_2 Dihydroorotase signature 2. ASDhAPHtleeK source prosite : PS00483 42) chain A residue 1686 type ACT_SITE sequence D description For DHOase activity => ECO:0000250|UniProtKB:P05020 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 1471 type BINDING sequence H description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 44) chain A residue 1473 type BINDING sequence H description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 45) chain A residue 1590 type BINDING sequence H description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 46) chain A residue 1613 type BINDING sequence C description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 47) chain A residue 1614 type BINDING sequence H description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 48) chain A residue 1637 type BINDING sequence T description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 49) chain A residue 1686 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI2 50) chain A residue 1475 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q source Swiss-Prot : SWS_FT_FI3 51) chain A residue 1505 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q source Swiss-Prot : SWS_FT_FI3 52) chain A residue 1661 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q source Swiss-Prot : SWS_FT_FI3 53) chain A residue 1690 type BINDING sequence H description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q source Swiss-Prot : SWS_FT_FI3 54) chain A residue 1702 type BINDING sequence P description BINDING => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6Q source Swiss-Prot : SWS_FT_FI3 55) chain A residue 1556 type BINDING sequence X description via carbamate group => ECO:0000269|PubMed:24332717, ECO:0007744|PDB:4C6D source Swiss-Prot : SWS_FT_FI4 56) chain A residue 1556 type MOD_RES sequence X description N6-carboxylysine => ECO:0000269|PubMed:24332717 source Swiss-Prot : SWS_FT_FI5

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