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eF-site ID
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4c50-B |
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PDB Code
|
4c50 |
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Chain
|
B |
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click to enlarge
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Title
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Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis |
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Classification
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OXIDOREDUCTASE |
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Compound
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CATALASE-PEROXIDASE |
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Source
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(KATG_MYCTU) |
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Sequence
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B: |
HMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDY
AAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIR
MAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPSNASLDKA
RRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFG
FGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQ
MGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAA
LIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGWKSSY
GTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELT
KSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSL
RVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVA
RYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRA
SGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVG
WEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLV
VLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESF
AVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEM
TVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDM
GITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSEL
RALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR
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Description
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Functional site
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1)
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chain |
B |
| residue |
108 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01961
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
B |
| residue |
321 |
| type |
ACT_SITE |
| sequence |
W
|
| description |
Tryptophan radical intermediate => ECO:0000269|PubMed:18052167
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| source |
Swiss-Prot : SWS_FT_FI2
|
|
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3)
|
chain |
B |
| residue |
104 |
| type |
SITE |
| sequence |
R
|
| description |
Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_01961
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
4)
|
chain |
B |
| residue |
107 |
| type |
CROSSLNK |
| sequence |
W
|
| description |
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255); alternate => ECO:0000255|HAMAP-Rule:MF_01961, ECO:0000269|PubMed:15231843
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
5)
|
chain |
B |
| residue |
229 |
| type |
CROSSLNK |
| sequence |
Y
|
| description |
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate => ECO:0000255|HAMAP-Rule:MF_01961, ECO:0000269|PubMed:15231843
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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6)
|
chain |
B |
| residue |
255 |
| type |
CROSSLNK |
| sequence |
M
|
| description |
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate => ECO:0000255|HAMAP-Rule:MF_01961, ECO:0000269|PubMed:15231843
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
7)
|
chain |
B |
| residue |
270 |
| type |
BINDING |
| sequence |
H
|
| description |
axial binding residue => ECO:0000269|PubMed:15231843, ECO:0000269|PubMed:16566587, ECO:0000269|PubMed:24185282, ECO:0007744|PDB:1SJ2, ECO:0007744|PDB:2CCA, ECO:0007744|PDB:2CCD, ECO:0007744|PDB:4C51
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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|