eF-site ID 4c4x-B PDB Code 4c4x Chain B click to enlarge Title Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9 Classification HYDROLASE Compound BIFUNCTIONAL EPOXIDE HYDROLASE 2 Source (HYES_HUMAN) Sequence B:  PSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYS WRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVL CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVR AVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVA EAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSP EEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNW KWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPH LKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDAR Description Functional site 1) chain B residue 267 type sequence F description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 2) chain B residue 335 type sequence D description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 3) chain B residue 383 type sequence Y description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 4) chain B residue 408 type sequence L description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 5) chain B residue 419 type sequence M description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 6) chain B residue 466 type sequence Y description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 7) chain B residue 498 type sequence V description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 8) chain B residue 524 type sequence H description BINDING SITE FOR RESIDUE W9M B 1548 source : AC2 9) chain B residue 524 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 370 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P34914 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 421 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P34914 source Swiss-Prot : SWS_FT_FI6 12) chain B residue 455 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P34914 source Swiss-Prot : SWS_FT_FI6 13) chain B residue 522 type LIPID sequence C description S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine => ECO:0000305|PubMed:21164107 source Swiss-Prot : SWS_FT_FI7 14) chain B residue 383 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 source Swiss-Prot : SWS_FT_FI4 15) chain B residue 335 type ACT_SITE sequence D description Nucleophile => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 466 type ACT_SITE sequence Y description Proton donor => ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563, ECO:0000269|PubMed:19746975, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334 source Swiss-Prot : SWS_FT_FI2

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