eF-site ID 4c3h-ABCDEFGHIJKLMN PDB Code 4c3h Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N click to enlarge Title Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 Classification TRANSCRIPTION Compound DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 Source ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence A:  MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDN LGHPVSGGLYDLALGAFLRNLCSTCGLDEKFCPGHQGHIE LPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC KLRLLQYGLIDESYKLDEITLDISSTLLNELKSKRSEYVD MAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSR GKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFI RQDMISTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLS RKLVKADSFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLL SKVLTTSLLIRDLNDDLSKLKVSLEDRRVIFSRLMNAFVT IQNDVNAFIDSTKAQGRTVPIPGVKQALEKKEGLFRKHMM GKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVT AYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVE QRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQ PTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDE MNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQD HISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKI VTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISK NKIKNEYWGKGSLENEVLFKDGALLCGILDKSQYGASKYG IVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDD LRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADD PELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCV PDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQAL EGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKP QEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHV SYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDN YYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEP HYKQSVKYDPVLAKYNPAKYLGSVSENFQDKLESFLDKNS KGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPST QMTLNTFNVTLGIPRLREIVMTASAAIKTPQMTLPIWNDV SDEQADTFCKSISKVLLSEVIDKVIVTETTGTARSYVIHM RFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIK KQKRTTGPDIGVAVPRLQNSKRLEEDNDEEQSHKKTKQAV SYDEPDEDEIETMREAENMNKVQRDRQSAIISHHRFITKY NFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDG ITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFR HLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKV PNA B:  RTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNA LTEGPDGGLLNLGVKDIGEKVIFDGKPLNSEEISNSGYLG NKLSVSVEQVSIAKPMSNDSAVERKVYPSESRQRLTSYRG KLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKM SPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPM AIIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLND GQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGN DVKDSFLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFR VVFQASPDQSDLEVGQEVLDRIVLVHLGKDGSQDKFRMLL FMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKE KIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNE NIGSKMQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFYR FISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPD GSPCGLLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASH TFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEG KTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRY LPLDKEDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTN ILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALCH RSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAV ISYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALDP ITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICA YFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSE TGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHGIAQD STPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPV KGRKRHGGIRVGEMERDALIGHGTSFLLQDRLLNSSDYTQ ASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK GEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDS ELSAMGIRLRYNVEPK C:  EWNVEKFKKDFEVNISSLDAREANFDLINIDTSIANAFRR IMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVD PDMLTWVDSNLPDDEKFTDENTIVLSLNVKCTRNPDAPST DPKELYNNAHVYARDLKFEPQGRQSTTFADCPVVPADPDI LLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLP QINILQPIKGESARRFQKCFPPGVIGIDEGSDEAYVKDAR KDTVSREVLRYEEFADKVKLGRVRNHFIFNVESAGAMTPE EIFFKSVRILKNKAEYLKNCPITQ D:  SATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENTN LSSSISQLKRIQRDFKGLP E:  MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLE DFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWV EFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDE KRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIR KSETSGRYASYRICM F:  PEDFQQHEQIRRKTLKEKAIPKDQRATTPYMTKYERARIL GTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVI RRYLPDGSFEDWSVEELIVD G:  NENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYV SLAPMYLENPLQGVMKQHLNPLVMKYNNKVGGVVLGYEGL KILDADPLDTSEKLIKITPDTPFGFTWCHVNLYVWQPQVG DVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVH NDVELGHWVDSNGEPIDGKLRFTVRNVHTTGRVVSVDGTL ISYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDL PEVKEDNGSEIVYEENTSE H:  NTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDI NVELFPVAAQDSLTVTIASSLNATRSWRPPQAGDRSLADD YDYVMYGTAYKFEEVSKDLIAVYYSFGGLLMRLEGNYRNL NNLKQENAYLLIRR I:  SVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQ FSNLKVVTTTADDAFPSSLRAKKSVVKTSLKKNELKDGAT IKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYKF RTNN J:  MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLG LKRYCCRRMILTHVDLIEKFLRYNPLEKR K:  EEPDREKIKLLTQATSEDGTSASFQIVEEDHTLGNALRYV IMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQK GLKDLMDLCDVVESKFTEKIKSM L:  TLKYICAECSSKLSLSRTDAVRCKDCGHRILLKARTKRLV QFEAR M:  SEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKEKD EFVLHGENERLEYEGYTDSSSQASNQYVVGLFNPEKKSIQ LYKAPVLVSKVVSKSSKNLRGPKIK N:  FSIPDGFKKCKHLKNFPLNGDNKQQQVWLIKFPSNVDISK LKSLPVDFESSTTMTIDKHDYKIMDDTDNMTLLVPSESKE SLKIASTAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVP KVEGLKLEHFATGYDAEDF Description (1)  DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5, DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34 Functional site 1) chain A residue 102 type sequence C description BINDING SITE FOR RESIDUE ZN A 2664 source : AC1 2) chain A residue 105 type sequence C description BINDING SITE FOR RESIDUE ZN A 2664 source : AC1 3) chain A residue 233 type sequence C description BINDING SITE FOR RESIDUE ZN A 2664 source : AC1 4) chain A residue 236 type sequence C description BINDING SITE FOR RESIDUE ZN A 2664 source : AC1 5) chain A residue 62 type sequence C description BINDING SITE FOR RESIDUE ZN A 2665 source : AC2 6) chain A residue 65 type sequence C description BINDING SITE FOR RESIDUE ZN A 2665 source : AC2 7) chain A residue 72 type sequence C description BINDING SITE FOR RESIDUE ZN A 2665 source : AC2 8) chain A residue 75 type sequence H description BINDING SITE FOR RESIDUE ZN A 2665 source : AC2 9) chain B residue 1104 type sequence C description BINDING SITE FOR RESIDUE ZN B 2204 source : AC3 10) chain B residue 1107 type sequence C description BINDING SITE FOR RESIDUE ZN B 2204 source : AC3 11) chain B residue 1128 type sequence C description BINDING SITE FOR RESIDUE ZN B 2204 source : AC3 12) chain B residue 1131 type sequence C description BINDING SITE FOR RESIDUE ZN B 2204 source : AC3 13) chain L residue 31 type sequence C description BINDING SITE FOR RESIDUE ZN L 1071 source : AC4 14) chain L residue 34 type sequence C description BINDING SITE FOR RESIDUE ZN L 1071 source : AC4 15) chain L residue 48 type sequence C description BINDING SITE FOR RESIDUE ZN L 1071 source : AC4 16) chain L residue 51 type sequence C description BINDING SITE FOR RESIDUE ZN L 1071 source : AC4 17) chain J residue 7 type sequence C description BINDING SITE FOR RESIDUE ZN J 1070 source : AC5 18) chain J residue 10 type sequence C description BINDING SITE FOR RESIDUE ZN J 1070 source : AC5 19) chain J residue 45 type sequence C description BINDING SITE FOR RESIDUE ZN J 1070 source : AC5 20) chain J residue 46 type sequence C description BINDING SITE FOR RESIDUE ZN J 1070 source : AC5 21) chain I residue 10 type sequence C description BINDING SITE FOR RESIDUE ZN I 1126 source : AC6 22) chain I residue 13 type sequence C description BINDING SITE FOR RESIDUE ZN I 1126 source : AC6 23) chain I residue 30 type sequence C description BINDING SITE FOR RESIDUE ZN I 1126 source : AC6 24) chain I residue 33 type sequence C description BINDING SITE FOR RESIDUE ZN I 1126 source : AC6 25) chain I residue 86 type sequence C description BINDING SITE FOR RESIDUE ZN I 1127 source : AC7 26) chain I residue 89 type sequence C description BINDING SITE FOR RESIDUE ZN I 1127 source : AC7 27) chain I residue 114 type sequence C description BINDING SITE FOR RESIDUE ZN I 1127 source : AC7 28) chain I residue 117 type sequence C description BINDING SITE FOR RESIDUE ZN I 1127 source : AC7 29) chain J residue 45 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 30) chain J residue 46 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 102 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 105 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 233 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 236 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI1 35) chain J residue 2-11 type prosite sequence IVPVRCFSCG description RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IVPVrCFSCG source prosite : PS01112 36) chain F residue 86-100 type prosite sequence TKYERARILGTRALQ description RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ source prosite : PS01111 37) chain B residue 914-926 type prosite sequence GDKFSSRHGQKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKFSSrHGQKGV source prosite : PS01166 38) chain K residue 65-96 type prosite sequence IVEEDHTLGNALRYVIMKNPDVEFCGYSIPHP description RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. IveEdHTLgNaLryvImknpdVefcgYsipHP source prosite : PS01154 39) chain E residue 147-160 type prosite sequence HELVPKHIRLSSDE description RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLssDE source prosite : PS01110 40) chain C residue 65-105 type prosite sequence NAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLV P description RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NAFRRimisevpsvAaeyVyffnNtSviqDEvLAhRIGLVP source prosite : PS00446 41) chain I residue 86-121 type prosite sequence CPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYKF description ZF_TFIIS_1 Zinc finger TFIIS-type signature. CpqCgneemnyhtLQLRSaDEGatvfytCts...CgykF source prosite : PS00466 42) chain I residue 9-33 type prosite sequence FCLDCGDLLENPNAVLGSNVECSQC description RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FClDCGDLLenpnavlgsnve..CsqC source prosite : PS01030 43) chain L residue 34 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI2 44) chain L residue 48 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI2 45) chain L residue 51 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI2 46) chain N residue 60 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3 47) chain I residue 89 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3 48) chain I residue 114 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3 49) chain I residue 117 type MOD_RES sequence C description Phosphoserine => ECO:0007744|PubMed:18407956 source Swiss-Prot : SWS_FT_FI3 50) chain B residue 1156 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19779198 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links