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eF-site ID
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4c3h-A |
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PDB Code
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4c3h |
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Chain
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A |
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click to enlarge
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Title
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Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 |
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Classification
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TRANSCRIPTION |
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Compound
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DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 |
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Source
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ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; |
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Sequence
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A: |
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDN
LGHPVSGGLYDLALGAFLRNLCSTCGLDEKFCPGHQGHIE
LPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLDISSTLLNELKSKRSEYVD
MAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSR
GKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFI
RQDMISTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLS
RKLVKADSFFMDVLVVPPTRFRLPSKLGEEVHENSQNQLL
SKVLTTSLLIRDLNDDLSKLKVSLEDRRVIFSRLMNAFVT
IQNDVNAFIDSTKAQGRTVPIPGVKQALEKKEGLFRKHMM
GKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVT
AYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVE
QRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQ
PTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDGDE
MNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQD
HISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKI
VTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISK
NKIKNEYWGKGSLENEVLFKDGALLCGILDKSQYGASKYG
IVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDD
LRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADD
PELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCV
PDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQAL
EGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKP
QEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHV
SYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDN
YYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEP
HYKQSVKYDPVLAKYNPAKYLGSVSENFQDKLESFLDKNS
KGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPST
QMTLNTFNVTLGIPRLREIVMTASAAIKTPQMTLPIWNDV
SDEQADTFCKSISKVLLSEVIDKVIVTETTGTARSYVIHM
RFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIK
KQKRTTGPDIGVAVPRLQNSKRLEEDNDEEQSHKKTKQAV
SYDEPDEDEIETMREAENMNKVQRDRQSAIISHHRFITKY
NFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDG
ITSNDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFR
HLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKV
PNA
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Description
|
(1) |
DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA190 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA135 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA14, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5, DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49, DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34
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Functional site
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1)
|
chain |
A |
| residue |
102 |
| type |
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| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN A 2664
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| source |
: AC1
|
|
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2)
|
chain |
A |
| residue |
105 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2664
|
| source |
: AC1
|
|
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3)
|
chain |
A |
| residue |
233 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2664
|
| source |
: AC1
|
|
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4)
|
chain |
A |
| residue |
236 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2664
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
62 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2665
|
| source |
: AC2
|
|
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6)
|
chain |
A |
| residue |
65 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2665
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
72 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2665
|
| source |
: AC2
|
|
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8)
|
chain |
A |
| residue |
75 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 2665
|
| source |
: AC2
|
|
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9)
|
chain |
A |
| residue |
102 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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10)
|
chain |
A |
| residue |
105 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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11)
|
chain |
A |
| residue |
233 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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12)
|
chain |
A |
| residue |
236 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
|
| source |
Swiss-Prot : SWS_FT_FI1
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