eF-site ID 4c02-AB
PDB Code 4c02
Chain A, B

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Title Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin
Classification TRANSFERASE/ISOMERASE
Compound ACTIVIN RECEPTOR TYPE-1
Source (FKB1B_HUMAN)
Sequence A:  STLADLLDSGSGSGLPFLVQRTVARQITLLECVGKGRYGE
VWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN
ILGFIASDMTSRSTQLWLITHYHEMGSLYDYLQLTTLDTV
SCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNIL
VKKNGQCCIADLGLAVMHSQSTNQLDVPRVGTKRYMAPEV
LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVED
YKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPT
LTSLAKLMKECWYQNPSARLTALRIKKTLTKID
B:  MGVEIETISPGDGRTFPKKGQTCVVHYTGMLQNGKKFDSS
RDRNKPFKFRIGKQEVIKGFEEGAAQMSLGQRAKLTCTPD
VAYGATGHPGVIPPNATLIFDVELLNLE
Description


Functional site

1) chain A
residue 318
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1500
source : AC1

2) chain A
residue 321
type
sequence I
description BINDING SITE FOR RESIDUE FLC A 1500
source : AC1

3) chain A
residue 492
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1500
source : AC1

4) chain A
residue 325
type
sequence G
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

5) chain A
residue 363
type
sequence Q
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

6) chain B
residue 28
type
sequence T
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

7) chain B
residue 36
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

8) chain B
residue 39
type
sequence S
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

9) chain B
residue 41
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

10) chain B
residue 42
type
sequence D
description BINDING SITE FOR RESIDUE FLC A 1501
source : AC2

11) chain A
residue 284
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

12) chain A
residue 285
type
sequence Y
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

13) chain A
residue 286
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

14) chain A
residue 287
type
sequence E
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

15) chain A
residue 345
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

16) chain A
residue 346
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1502
source : AC3

17) chain A
residue 258
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

18) chain A
residue 259
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

19) chain A
residue 260
type
sequence E
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

20) chain A
residue 262
type
sequence I
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

21) chain A
residue 263
type
sequence L
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

22) chain A
residue 264
type
sequence G
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

23) chain A
residue 284
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

24) chain A
residue 286
type
sequence H
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

25) chain A
residue 345
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1503
source : AC4

26) chain A
residue 338
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

27) chain A
residue 340
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

28) chain A
residue 380
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

29) chain A
residue 437
type
sequence N
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

30) chain A
residue 438
type
sequence D
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

31) chain A
residue 439
type
sequence P
description BINDING SITE FOR RESIDUE FLC A 1504
source : AC5

32) chain A
residue 487
type
sequence T
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

33) chain A
residue 489
type
sequence L
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

34) chain A
residue 490
type
sequence R
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

35) chain A
residue 493
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

36) chain B
residue 48
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

37) chain B
residue 108
type
sequence E
description BINDING SITE FOR RESIDUE FLC A 1505
source : AC6

38) chain A
residue 321
type
sequence I
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

39) chain A
residue 400
type
sequence K
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

40) chain A
residue 487
type
sequence T
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

41) chain A
residue 488
type
sequence A
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

42) chain A
residue 489
type
sequence L
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

43) chain B
residue 105
type
sequence L
description BINDING SITE FOR RESIDUE FLC A 1506
source : AC7

44) chain A
residue 270
type
sequence M
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

45) chain B
residue 82
type
sequence A
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

46) chain B
residue 83
type
sequence Y
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

47) chain B
residue 84
type
sequence G
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

48) chain B
residue 85
type
sequence A
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

49) chain B
residue 86
type
sequence T
description BINDING SITE FOR RESIDUE FLC B 1108
source : AC8

50) chain A
residue 222
type
sequence V
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

51) chain A
residue 233
type
sequence A
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

52) chain A
residue 263
type
sequence L
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

53) chain A
residue 283
type
sequence T
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

54) chain A
residue 284
type
sequence H
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

55) chain A
residue 285
type
sequence Y
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

56) chain A
residue 286
type
sequence H
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

57) chain A
residue 287
type
sequence E
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

58) chain A
residue 289
type
sequence G
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

59) chain A
residue 343
type
sequence L
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

60) chain A
residue 354
type
sequence D
description BINDING SITE FOR RESIDUE TAK A 1507
source : AC9

61) chain B
residue 31
type
sequence L
description BINDING SITE FOR RESIDUE EDO B 1109
source : BC1

62) chain B
residue 33
type
sequence N
description BINDING SITE FOR RESIDUE EDO B 1109
source : BC1

63) chain A
residue 431
type
sequence F
description BINDING SITE FOR RESIDUE EDO A 1508
source : BC2

64) chain A
residue 433
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1508
source : BC2

65) chain A
residue 454
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 1508
source : BC2

66) chain A
residue 456
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 1508
source : BC2

67) chain B
residue 47
type
sequence F
description BINDING SITE FOR RESIDUE EDO B 1110
source : BC3

68) chain B
residue 48
type
sequence K
description BINDING SITE FOR RESIDUE EDO B 1110
source : BC3

69) chain A
residue 395
type
sequence C
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

70) chain A
residue 397
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

71) chain A
residue 398
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

72) chain A
residue 401
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

73) chain A
residue 482
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

74) chain A
residue 483
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

75) chain B
residue 12
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

76) chain B
residue 14
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 1509
source : BC4

77) chain A
residue 260
type
sequence E
description BINDING SITE FOR RESIDUE EDO A 1510
source : BC5

78) chain A
residue 345
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 1510
source : BC5

79) chain A
residue 347
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 1510
source : BC5

80) chain A
residue 302
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1511
source : BC6

81) chain A
residue 454
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 1512
source : BC7

82) chain A
residue 455
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 1512
source : BC7

83) chain A
residue 475
type
sequence K
description BINDING SITE FOR RESIDUE EDO A 1512
source : BC7

84) chain A
residue 478
type
sequence W
description BINDING SITE FOR RESIDUE EDO A 1512
source : BC7

85) chain A
residue 265
type
sequence F
description BINDING SITE FOR RESIDUE EDO A 1513
source : BC8

86) chain A
residue 284
type
sequence H
description BINDING SITE FOR RESIDUE EDO A 1513
source : BC8

87) chain B
residue 10
type
sequence P
description BINDING SITE FOR RESIDUE EDO B 1111
source : BC9

88) chain B
residue 11
type
sequence G
description BINDING SITE FOR RESIDUE EDO B 1111
source : BC9

89) chain B
residue 68
type
sequence S
description BINDING SITE FOR RESIDUE EDO B 1111
source : BC9

90) chain B
residue 71
type
sequence Q
description BINDING SITE FOR RESIDUE EDO B 1111
source : BC9

91) chain A
residue 206
type
sequence R
description BINDING SITE FOR RESIDUE EDO A 1514
source : CC1

92) chain B
residue 54
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 1514
source : CC1

93) chain A
residue 212
type
sequence E
description BINDING SITE FOR RESIDUE EDO A 1515
source : CC2

94) chain A
residue 299
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1515
source : CC2

95) chain A
residue 419
type
sequence V
description BINDING SITE FOR RESIDUE EDO A 1515
source : CC2

96) chain A
residue 231
type
sequence N
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

97) chain A
residue 287
type
sequence E
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

98) chain A
residue 298
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

99) chain A
residue 299
type
sequence T
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

100) chain A
residue 300
type
sequence L
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

101) chain A
residue 301
type
sequence D
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

102) chain A
residue 304
type
sequence S
description BINDING SITE FOR RESIDUE EDO A 1516
source : CC3

103) chain A
residue 446
type
sequence K
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

104) chain A
residue 450
type
sequence V
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

105) chain A
residue 451
type
sequence D
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

106) chain B
residue 51
type
sequence I
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

107) chain B
residue 52
type
sequence G
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

108) chain B
residue 61
type
sequence E
description BINDING SITE FOR RESIDUE EDO B 1112
source : CC4

109) chain A
residue 214-235
type prosite
sequence VGKGRYGEVWRGSWQGENVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK
source prosite : PS00107

110) chain A
residue 332-344
type prosite
sequence IAHRDLKSKNILV
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV
source prosite : PS00108

111) chain A
residue 336
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

112) chain A
residue 214
type BINDING
sequence V
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

113) chain A
residue 235
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2


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