eF-site ID 4c02-A PDB Code 4c02 Chain A click to enlarge Title Crystal structure of human ACVR1 (ALK2) in complex with FKBP12.6 and dorsomorphin Classification TRANSFERASE/ISOMERASE Compound ACTIVIN RECEPTOR TYPE-1 Source (FKB1B_HUMAN) Sequence A:  STLADLLDSGSGSGLPFLVQRTVARQITLLECVGKGRYGE VWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHEN ILGFIASDMTSRSTQLWLITHYHEMGSLYDYLQLTTLDTV SCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNIL VKKNGQCCIADLGLAVMHSQSTNQLDVPRVGTKRYMAPEV LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVED YKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPT LTSLAKLMKECWYQNPSARLTALRIKKTLTKID Description Functional site 1) chain A residue 318 type sequence H description BINDING SITE FOR RESIDUE FLC A 1500 source : AC1 2) chain A residue 321 type sequence I description BINDING SITE FOR RESIDUE FLC A 1500 source : AC1 3) chain A residue 492 type sequence K description BINDING SITE FOR RESIDUE FLC A 1500 source : AC1 4) chain A residue 325 type sequence G description BINDING SITE FOR RESIDUE FLC A 1501 source : AC2 5) chain A residue 363 type sequence Q description BINDING SITE FOR RESIDUE FLC A 1501 source : AC2 6) chain A residue 284 type sequence H description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 7) chain A residue 285 type sequence Y description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 8) chain A residue 286 type sequence H description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 9) chain A residue 287 type sequence E description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 10) chain A residue 345 type sequence K description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 11) chain A residue 346 type sequence K description BINDING SITE FOR RESIDUE FLC A 1502 source : AC3 12) chain A residue 258 type sequence R description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 13) chain A residue 259 type sequence H description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 14) chain A residue 260 type sequence E description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 15) chain A residue 262 type sequence I description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 16) chain A residue 263 type sequence L description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 17) chain A residue 264 type sequence G description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 18) chain A residue 284 type sequence H description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 19) chain A residue 286 type sequence H description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 20) chain A residue 345 type sequence K description BINDING SITE FOR RESIDUE FLC A 1503 source : AC4 21) chain A residue 338 type sequence K description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 22) chain A residue 340 type sequence K description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 23) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 24) chain A residue 437 type sequence N description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 25) chain A residue 438 type sequence D description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 26) chain A residue 439 type sequence P description BINDING SITE FOR RESIDUE FLC A 1504 source : AC5 27) chain A residue 487 type sequence T description BINDING SITE FOR RESIDUE FLC A 1505 source : AC6 28) chain A residue 489 type sequence L description BINDING SITE FOR RESIDUE FLC A 1505 source : AC6 29) chain A residue 490 type sequence R description BINDING SITE FOR RESIDUE FLC A 1505 source : AC6 30) chain A residue 493 type sequence K description BINDING SITE FOR RESIDUE FLC A 1505 source : AC6 31) chain A residue 321 type sequence I description BINDING SITE FOR RESIDUE FLC A 1506 source : AC7 32) chain A residue 400 type sequence K description BINDING SITE FOR RESIDUE FLC A 1506 source : AC7 33) chain A residue 487 type sequence T description BINDING SITE FOR RESIDUE FLC A 1506 source : AC7 34) chain A residue 488 type sequence A description BINDING SITE FOR RESIDUE FLC A 1506 source : AC7 35) chain A residue 489 type sequence L description BINDING SITE FOR RESIDUE FLC A 1506 source : AC7 36) chain A residue 270 type sequence M description BINDING SITE FOR RESIDUE FLC B 1108 source : AC8 37) chain A residue 222 type sequence V description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 38) chain A residue 233 type sequence A description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 39) chain A residue 263 type sequence L description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 40) chain A residue 283 type sequence T description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 41) chain A residue 284 type sequence H description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 42) chain A residue 285 type sequence Y description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 43) chain A residue 286 type sequence H description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 44) chain A residue 287 type sequence E description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 45) chain A residue 289 type sequence G description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 46) chain A residue 343 type sequence L description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 47) chain A residue 354 type sequence D description BINDING SITE FOR RESIDUE TAK A 1507 source : AC9 48) chain A residue 431 type sequence F description BINDING SITE FOR RESIDUE EDO A 1508 source : BC2 49) chain A residue 433 type sequence D description BINDING SITE FOR RESIDUE EDO A 1508 source : BC2 50) chain A residue 454 type sequence R description BINDING SITE FOR RESIDUE EDO A 1508 source : BC2 51) chain A residue 456 type sequence N description BINDING SITE FOR RESIDUE EDO A 1508 source : BC2 52) chain A residue 395 type sequence C description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 53) chain A residue 397 type sequence D description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 54) chain A residue 398 type sequence S description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 55) chain A residue 401 type sequence R description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 56) chain A residue 482 type sequence P description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 57) chain A residue 483 type sequence S description BINDING SITE FOR RESIDUE EDO A 1509 source : BC4 58) chain A residue 260 type sequence E description BINDING SITE FOR RESIDUE EDO A 1510 source : BC5 59) chain A residue 345 type sequence K description BINDING SITE FOR RESIDUE EDO A 1510 source : BC5 60) chain A residue 347 type sequence N description BINDING SITE FOR RESIDUE EDO A 1510 source : BC5 61) chain A residue 302 type sequence T description BINDING SITE FOR RESIDUE EDO A 1511 source : BC6 62) chain A residue 454 type sequence R description BINDING SITE FOR RESIDUE EDO A 1512 source : BC7 63) chain A residue 455 type sequence P description BINDING SITE FOR RESIDUE EDO A 1512 source : BC7 64) chain A residue 475 type sequence K description BINDING SITE FOR RESIDUE EDO A 1512 source : BC7 65) chain A residue 478 type sequence W description BINDING SITE FOR RESIDUE EDO A 1512 source : BC7 66) chain A residue 265 type sequence F description BINDING SITE FOR RESIDUE EDO A 1513 source : BC8 67) chain A residue 284 type sequence H description BINDING SITE FOR RESIDUE EDO A 1513 source : BC8 68) chain A residue 206 type sequence R description BINDING SITE FOR RESIDUE EDO A 1514 source : CC1 69) chain A residue 212 type sequence E description BINDING SITE FOR RESIDUE EDO A 1515 source : CC2 70) chain A residue 299 type sequence T description BINDING SITE FOR RESIDUE EDO A 1515 source : CC2 71) chain A residue 419 type sequence V description BINDING SITE FOR RESIDUE EDO A 1515 source : CC2 72) chain A residue 231 type sequence N description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 73) chain A residue 287 type sequence E description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 74) chain A residue 298 type sequence T description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 75) chain A residue 299 type sequence T description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 76) chain A residue 300 type sequence L description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 77) chain A residue 301 type sequence D description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 78) chain A residue 304 type sequence S description BINDING SITE FOR RESIDUE EDO A 1516 source : CC3 79) chain A residue 446 type sequence K description BINDING SITE FOR RESIDUE EDO B 1112 source : CC4 80) chain A residue 450 type sequence V description BINDING SITE FOR RESIDUE EDO B 1112 source : CC4 81) chain A residue 451 type sequence D description BINDING SITE FOR RESIDUE EDO B 1112 source : CC4 82) chain A residue 214-235 type prosite sequence VGKGRYGEVWRGSWQGENVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK source prosite : PS00107 83) chain A residue 332-344 type prosite sequence IAHRDLKSKNILV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV source prosite : PS00108 84) chain A residue 336 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 214 type BINDING sequence V description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 86) chain A residue 235 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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