|
|
eF-site ID
|
4byf-D |
|
PDB Code
|
4byf |
|
Chain
|
D |
|
click to enlarge
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Title
|
Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state |
|
Classification
|
HYDROLASE |
|
Compound
|
UNCONVENTIONAL MYOSIN-IC |
|
Source
|
Homo sapiens (Human) (CALM_HUMAN) |
|
|
Sequence
|
D: |
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLG
QNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTD
SEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK
|
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|
Description
|
|
Functional site
|
|
|
1)
|
chain |
D |
| residue |
94 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG D 1000
|
| source |
: AC5
|
|
|
2)
|
chain |
D |
| residue |
96 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG D 1000
|
| source |
: AC5
|
|
|
3)
|
chain |
D |
| residue |
98 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE MG D 1000
|
| source |
: AC5
|
|
|
4)
|
chain |
D |
| residue |
100 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE MG D 1000
|
| source |
: AC5
|
|
|
5)
|
chain |
D |
| residue |
82 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
6)
|
chain |
D |
| residue |
111 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine => ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI10
|
|
|
7)
|
chain |
D |
| residue |
116 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
|
| source |
Swiss-Prot : SWS_FT_FI11
|
|
|
8)
|
chain |
D |
| residue |
139 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:19690332
|
| source |
Swiss-Prot : SWS_FT_FI12
|
|
|
9)
|
chain |
D |
| residue |
21 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
D |
| residue |
23 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
11)
|
chain |
D |
| residue |
25 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
D |
| residue |
27 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
D |
| residue |
32 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
14)
|
chain |
D |
| residue |
57 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
15)
|
chain |
D |
| residue |
59 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
16)
|
chain |
D |
| residue |
61 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
17)
|
chain |
D |
| residue |
63 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
18)
|
chain |
D |
| residue |
68 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
19)
|
chain |
D |
| residue |
2 |
| type |
MOD_RES |
| sequence |
A
|
| description |
N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
20)
|
chain |
D |
| residue |
45 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
21)
|
chain |
D |
| residue |
94 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
22)
|
chain |
D |
| residue |
96 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
23)
|
chain |
D |
| residue |
98 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
24)
|
chain |
D |
| residue |
100 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
25)
|
chain |
D |
| residue |
105 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
26)
|
chain |
D |
| residue |
130 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
27)
|
chain |
D |
| residue |
132 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
28)
|
chain |
D |
| residue |
134 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
29)
|
chain |
D |
| residue |
136 |
| type |
BINDING |
| sequence |
Q
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
30)
|
chain |
D |
| residue |
141 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
31)
|
chain |
D |
| residue |
22 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
32)
|
chain |
D |
| residue |
22 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
|
| source |
Swiss-Prot : SWS_FT_FI13
|
|
|
33)
|
chain |
D |
| residue |
95 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
34)
|
chain |
D |
| residue |
100 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
35)
|
chain |
D |
| residue |
102 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
|