eF-site ID 4bvw-AB PDB Code 4bvw Chain A, B click to enlarge Title Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. Classification HYDROLASE Compound APOLIPOPROTEIN(A) Source Homo sapiens (Human) (APOA_HUMAN) Sequence A:  DCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEY YPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCALTQC B:  DCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEY YPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCALTQC Description Functional site 1) chain A residue 3 type sequence H description BINDING SITE FOR RESIDUE CL A 1079 source : AC1 2) chain A residue 8 type sequence S description BINDING SITE FOR RESIDUE CL A 1079 source : AC1 3) chain A residue 9 type sequence Y description BINDING SITE FOR RESIDUE CL A 1079 source : AC1 4) chain B residue 40 type sequence Y description BINDING SITE FOR RESIDUE CL B 1079 source : AC2 5) chain B residue 41 type sequence P description BINDING SITE FOR RESIDUE CL B 1079 source : AC2 6) chain B residue 42 type sequence N description BINDING SITE FOR RESIDUE CL B 1079 source : AC2 7) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE CL B 1079 source : AC2 8) chain A residue 35 type sequence R description BINDING SITE FOR RESIDUE CL A 1081 source : AC3 9) chain B residue 2 type sequence Y description BINDING SITE FOR RESIDUE CL B 1080 source : AC4 10) chain B residue 77 type sequence Q description BINDING SITE FOR RESIDUE CL B 1080 source : AC4 11) chain A residue 20 type sequence R description BINDING SITE FOR RESIDUE EDO B 1081 source : AC5 12) chain B residue 2 type sequence Y description BINDING SITE FOR RESIDUE EDO B 1081 source : AC5 13) chain B residue 57 type sequence I description BINDING SITE FOR RESIDUE EDO B 1081 source : AC5 14) chain B residue 77 type sequence Q description BINDING SITE FOR RESIDUE EDO B 1081 source : AC5 15) chain A residue 54 type sequence D description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 16) chain A residue 56 type sequence E description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 17) chain A residue 60 type sequence W description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 18) chain A residue 62 type sequence Y description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 19) chain A residue 69 type sequence R description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 20) chain A residue 70 type sequence W description BINDING SITE FOR RESIDUE HKY A 1080 source : AC6 21) chain B residue 54 type sequence D description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 22) chain B residue 56 type sequence E description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 23) chain B residue 60 type sequence W description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 24) chain B residue 62 type sequence Y description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 25) chain B residue 69 type sequence R description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 26) chain B residue 70 type sequence W description BINDING SITE FOR RESIDUE HKY B 1082 source : AC7 27) chain A residue 49-61 type prosite sequence YCRNPDAEIRPWC description KRINGLE_1 Kringle domain signature. YCRNpdaeirp.WC source prosite : PS00021

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