eF-site ID 4bvn-A PDB Code 4bvn Chain A click to enlarge Title Ultra-thermostable beta1-adrenoceptor with cyanopindolol bound Classification SIGNALING PROTEIN Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTL TNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCE LWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTR ARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQD PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAK EQIRKRKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLV NIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILCRSPDF RKAFKRLLA Description Functional site 1) chain A residue 87 type sequence D description BINDING SITE FOR RESIDUE NA A 1359 source : AC1 2) chain A residue 128 type sequence S description BINDING SITE FOR RESIDUE NA A 1359 source : AC1 3) chain A residue 192 type sequence C description BINDING SITE FOR RESIDUE NA A 1360 source : AC2 4) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE NA A 1360 source : AC2 5) chain A residue 198 type sequence C description BINDING SITE FOR RESIDUE NA A 1360 source : AC2 6) chain A residue 172 type sequence V description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 7) chain A residue 176 type sequence P description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 8) chain A residue 181 type sequence W description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 9) chain A residue 183 type sequence R description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 10) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 11) chain A residue 209 type sequence I description BINDING SITE FOR RESIDUE OLC A 2001 source : AC3 12) chain A residue 107 type sequence W description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 13) chain A residue 108 type sequence L description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 14) chain A residue 109 type sequence W description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 15) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 16) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 17) chain A residue 231 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 18) chain A residue 287 type sequence K description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 19) chain A residue 290 type sequence K description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 20) chain A residue 293 type sequence G description BINDING SITE FOR RESIDUE OLC A 2002 source : AC4 21) chain A residue 227 type sequence A description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 22) chain A residue 231 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 23) chain A residue 286 type sequence H description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 24) chain A residue 287 type sequence K description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 25) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 26) chain A residue 296 type sequence M description BINDING SITE FOR RESIDUE OLC A 2003 source : AC5 27) chain A residue 322 type sequence K description BINDING SITE FOR RESIDUE OLC A 2004 source : AC6 28) chain A residue 326 type sequence V description BINDING SITE FOR RESIDUE OLC A 2004 source : AC6 29) chain A residue 140 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2005 source : AC7 30) chain A residue 140 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2005 source : AC7 31) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE OLC A 2005 source : AC7 32) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE OLC A 2005 source : AC7 33) chain A residue 137 type sequence I description BINDING SITE FOR RESIDUE OLC A 2006 source : AC8 34) chain A residue 137 type sequence I description BINDING SITE FOR RESIDUE OLC A 2006 source : AC8 35) chain A residue 138 type sequence D description BINDING SITE FOR RESIDUE OLC A 2006 source : AC8 36) chain A residue 225 type sequence F description BINDING SITE FOR RESIDUE OLC A 2006 source : AC8 37) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 38) chain A residue 75 type sequence L description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 39) chain A residue 139 type sequence R description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 40) chain A residue 142 type sequence A description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 41) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 42) chain A residue 149 type sequence Y description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 43) chain A residue 285 type sequence E description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 44) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE OLC A 2007 source : AC9 45) chain A residue 117 type sequence W description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 46) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 47) chain A residue 122 type sequence V description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 48) chain A residue 203 type sequence T description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 49) chain A residue 208 type sequence A description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 50) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 51) chain A residue 215 type sequence S description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 52) chain A residue 303 type sequence W description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 53) chain A residue 306 type sequence F description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 54) chain A residue 307 type sequence F description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 55) chain A residue 310 type sequence N description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 56) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 57) chain A residue 333 type sequence Y description BINDING SITE FOR RESIDUE P32 A 1361 source : BC1 58) chain A residue 110 type sequence G description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 59) chain A residue 111 type sequence S description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 60) chain A residue 196 type sequence P description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 61) chain A residue 287 type sequence K description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 62) chain A residue 290 type sequence K description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 63) chain A residue 291 type sequence T description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 64) chain A residue 345 type sequence R description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 65) chain A residue 346 type sequence S description BINDING SITE FOR RESIDUE MHA A 1362 source : BC2 66) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 232-313 type TOPO_DOM sequence REAKEQIRKRKTSRVMLMREHKALKTLGIIMGVFTLCWLP FFLVNIVN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 70) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 71) chain A residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 72) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 73) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 74) chain A residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 75) chain A residue 127-143 type prosite sequence ASVETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVeTLCVIAIDRYLaI source prosite : PS00237 76) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 77) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 78) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASVETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 79) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 80) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 81) chain A residue 314-343 type TRANSMEM sequence VFNRDLVPKWLFVAFNWLGYANSAMNPIIL description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8

Display surface Download Links