eF-site ID 4bv5-AB PDB Code 4bv5 Chain A, B click to enlarge Title Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV. Classification HYDROLASE Compound APOLIPOPROTEIN(A) Source Homo sapiens (Human) (APOA_HUMAN) Sequence A:  CYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENY PNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCALTRC B:  CYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENY PNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCALTRC Description Functional site 1) chain A residue 33 type sequence H description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 2) chain A residue 34 type sequence Q description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 3) chain A residue 35 type sequence R description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 4) chain A residue 55 type sequence D description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 5) chain A residue 57 type sequence D description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 6) chain A residue 62 type sequence W description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 7) chain A residue 64 type sequence F description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 8) chain A residue 71 type sequence R description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 9) chain A residue 72 type sequence W description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 10) chain B residue 67 type sequence D description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 11) chain B residue 68 type sequence P description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 12) chain B residue 69 type sequence S description BINDING SITE FOR RESIDUE 5C3 A 1081 source : AC1 13) chain A residue 67 type sequence D description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 14) chain A residue 68 type sequence P description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 15) chain A residue 69 type sequence S description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 16) chain B residue 33 type sequence H description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 17) chain B residue 34 type sequence Q description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 18) chain B residue 35 type sequence R description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 19) chain B residue 55 type sequence D description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 20) chain B residue 57 type sequence D description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 21) chain B residue 62 type sequence W description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 22) chain B residue 71 type sequence R description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 23) chain B residue 72 type sequence W description BINDING SITE FOR RESIDUE 5C3 B 1081 source : AC2 24) chain A residue 50-63 type prosite sequence YCRNPDADTGPWC description KRINGLE_1 Kringle domain signature. YCRNpdadtgp.WC source prosite : PS00021

Display surface Download Links