eF-site ID 4buy-A PDB Code 4buy Chain A click to enlarge Title Crystal structure of human tankyrase 2 in complex with 5-methyl-5-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)imidazolidine-2,4-dione Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC2 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2162 source : AC2 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC2 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC2 5) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 6) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 7) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 8) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 9) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 10) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 11) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 12) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 13) chain A residue 1034 type sequence P description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 14) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 15) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 16) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 17) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 18) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 19) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 20) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 21) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 22) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE F37 A 2164 source : AC5 23) chain A residue 1128 type sequence R description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 24) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 25) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 26) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 27) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 28) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 29) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2165 source : AC7 30) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2166 source : AC8 31) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2166 source : AC8 32) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2166 source : AC8 33) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2166 source : AC8 34) chain A residue 999 type sequence K description BINDING SITE FOR RESIDUE PEG A 2167 source : BC2 35) chain A residue 1006 type sequence W description BINDING SITE FOR RESIDUE PEG A 2167 source : BC2 36) chain A residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG A 2167 source : BC2 37) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links