eF-site ID 4bux-AC PDB Code 4bux Chain A, C click to enlarge Title Crystal structure of human tankyrase 2 in complex with 3-((4-(4-oxo-3, 4-dihydroquinazolin-2-yl)phenyl)methyl)imidazolidine-2,4-dione Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE C:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description Functional site 1) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 2) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 3) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 4) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2162 source : AC1 5) chain C residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN C 2162 source : AC2 6) chain C residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN C 2162 source : AC2 7) chain C residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN C 2162 source : AC2 8) chain C residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN C 2162 source : AC2 9) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2163 source : AC3 10) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2163 source : AC3 11) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2163 source : AC3 12) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2163 source : AC3 13) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2163 source : AC3 14) chain C residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 C 2163 source : AC4 15) chain C residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 C 2163 source : AC4 16) chain C residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 C 2163 source : AC4 17) chain C residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 C 2163 source : AC4 18) chain C residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 2163 source : AC4 19) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC5 20) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC5 21) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC5 22) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC5 23) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC5 24) chain C residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 C 2164 source : AC6 25) chain C residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 C 2164 source : AC6 26) chain C residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 C 2164 source : AC6 27) chain C residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 C 2164 source : AC6 28) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2165 source : AC7 29) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2165 source : AC7 30) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2165 source : AC7 31) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2165 source : AC7 32) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 33) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 34) chain A residue 1034 type sequence P description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 35) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 36) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 37) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 38) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 39) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 40) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 41) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 42) chain A residue 1075 type sequence I description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 43) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE F35 A 2166 source : AC8 44) chain C residue 1031 type sequence H description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 45) chain C residue 1032 type sequence G description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 46) chain C residue 1034 type sequence P description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 47) chain C residue 1035 type sequence F description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 48) chain C residue 1049 type sequence A description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 49) chain C residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 50) chain C residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 51) chain C residue 1067 type sequence K description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 52) chain C residue 1068 type sequence S description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 53) chain C residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 54) chain C residue 1075 type sequence I description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 55) chain C residue 1138 type sequence E description BINDING SITE FOR RESIDUE F35 C 2165 source : AC9 56) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 60) chain C residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 61) chain C residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 62) chain C residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 63) chain C residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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