eF-site ID 4but-B PDB Code 4but Chain B click to enlarge Title Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-3,4- dihydroquinazolin-2-yl)benzene-1-sulfonamide Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 2) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 3) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 4) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 5) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 6) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 7) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 8) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 9) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 10) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 11) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 12) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 13) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 14) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 15) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 16) chain B residue 1034 type sequence P description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 17) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 18) chain B residue 1047 type sequence R description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 19) chain B residue 1049 type sequence A description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 20) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 21) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 22) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 23) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 24) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 25) chain B residue 1075 type sequence I description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 26) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 27) chain B residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 28) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 29) chain B residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 30) chain B residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 31) chain B residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 32) chain B residue 1001 type sequence C description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 33) chain B residue 1002 type sequence N description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 34) chain B residue 1100 type sequence R description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 35) chain B residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 36) chain B residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 37) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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