eF-site ID 4but-AB PDB Code 4but Chain A, B click to enlarge Title Crystal structure of human tankyrase 2 in complex with 4-(4-oxo-3,4- dihydroquinazolin-2-yl)benzene-1-sulfonamide Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 2) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 3) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 4) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 3162 source : AC1 5) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 3162 source : AC2 6) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 3162 source : AC2 7) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 3162 source : AC2 8) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 3162 source : AC2 9) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3163 source : AC3 10) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 3163 source : AC3 11) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3163 source : AC3 12) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 3163 source : AC3 13) chain A residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 3163 source : AC3 14) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 15) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 16) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 17) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 18) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 3163 source : AC4 19) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 20) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 21) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 22) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 3164 source : AC5 23) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 3164 source : AC6 24) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 3164 source : AC6 25) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 3164 source : AC6 26) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 3164 source : AC6 27) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 28) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 29) chain A residue 1033 type sequence S description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 30) chain A residue 1034 type sequence P description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 31) chain A residue 1035 type sequence F description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 32) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 33) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 34) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 35) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 36) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 37) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 38) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE 31F A 3165 source : AC7 39) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 40) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 41) chain B residue 1034 type sequence P description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 42) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 43) chain B residue 1047 type sequence R description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 44) chain B residue 1049 type sequence A description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 45) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 46) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 47) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 48) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 49) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 50) chain B residue 1075 type sequence I description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 51) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE 31F B 3165 source : AC8 52) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 3166 source : AC9 53) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 3166 source : AC9 54) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 3166 source : AC9 55) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 3166 source : AC9 56) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 3166 source : AC9 57) chain B residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 58) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 59) chain B residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 60) chain B residue 988 type sequence I description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 61) chain B residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL B 3166 source : BC1 62) chain B residue 1001 type sequence C description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 63) chain B residue 1002 type sequence N description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 64) chain B residue 1100 type sequence R description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 65) chain B residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 66) chain B residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG B 3167 source : BC2 67) chain A residue 1006 type sequence W description BINDING SITE FOR RESIDUE PEG A 3167 source : BC3 68) chain A residue 1148 type sequence Y description BINDING SITE FOR RESIDUE PEG A 3167 source : BC3 69) chain A residue 1150 type sequence E description BINDING SITE FOR RESIDUE PEG A 3167 source : BC3 70) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 71) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 72) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 73) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 77) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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