eF-site ID 4buf-B PDB Code 4buf Chain B click to enlarge Title Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 2) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 3) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 4) chain B residue 1049 type sequence A description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 5) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 6) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 7) chain B residue 1061 type sequence F description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 8) chain B residue 1062 type sequence A description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 9) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 10) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 11) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 12) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 13) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 14) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 15) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 16) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 17) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 18) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 19) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 20) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 21) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 22) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 23) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 24) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 25) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 26) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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