eF-site ID 4buf-AB PDB Code 4buf Chain A, B click to enlarge Title Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE B:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEY LITYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 2) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 3) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 4) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 5) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 6) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 7) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 8) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 9) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 10) chain B residue 1031 type sequence H description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 11) chain B residue 1032 type sequence G description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 12) chain B residue 1035 type sequence F description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 13) chain B residue 1049 type sequence A description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 14) chain B residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 15) chain B residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 16) chain B residue 1061 type sequence F description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 17) chain B residue 1062 type sequence A description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 18) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 19) chain B residue 1068 type sequence S description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 20) chain B residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 21) chain B residue 1138 type sequence E description BINDING SITE FOR RESIDUE F36 B 2162 source : AC2 22) chain B residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 23) chain B residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 24) chain B residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 25) chain B residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 26) chain B residue 1070 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 2163 source : AC3 27) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 28) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 29) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 30) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 31) chain B residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 32) chain B residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 33) chain B residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 34) chain B residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 B 2164 source : AC5 35) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 36) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 37) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 38) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 39) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 40) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 41) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 42) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 43) chain B residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 44) chain B residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 45) chain B residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 46) chain B residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN B 2165 source : AC8 47) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 48) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 49) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 50) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 51) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 52) chain A residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 53) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 54) chain A residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 55) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 56) chain A residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 57) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 58) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 61) chain B residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 62) chain B residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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