eF-site ID 4buf-A PDB Code 4buf Chain A click to enlarge Title Crystal structure of human tankyrase 2 in complex with 2-(4- acetylphenyl)-3,4-dihydroquinazolin-4-one Classification TRANSFERASE Compound TANKYRASE-2 Source (TNKS2_HUMAN) Sequence A:  GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR YNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFH GSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQY VYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFS AMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI TYQIMRPE Description (1)  TANKYRASE-2 (E.C.2.4.2.30) Functional site 1) chain A residue 1031 type sequence H description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 2) chain A residue 1032 type sequence G description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 3) chain A residue 1049 type sequence A description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 4) chain A residue 1050 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 5) chain A residue 1060 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 6) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 7) chain A residue 1068 type sequence S description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 8) chain A residue 1071 type sequence Y description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 9) chain A residue 1138 type sequence E description BINDING SITE FOR RESIDUE F36 A 2162 source : AC1 10) chain A residue 977 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 11) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 12) chain A residue 980 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 13) chain A residue 1067 type sequence K description BINDING SITE FOR RESIDUE SO4 A 2163 source : AC4 14) chain A residue 990 type sequence N description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 15) chain A residue 991 type sequence R description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 16) chain A residue 1160 type sequence P description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 17) chain A residue 1161 type sequence E description BINDING SITE FOR RESIDUE SO4 A 2164 source : AC6 18) chain A residue 1081 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 19) chain A residue 1084 type sequence H description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 20) chain A residue 1089 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 21) chain A residue 1092 type sequence C description BINDING SITE FOR RESIDUE ZN A 2165 source : AC7 22) chain A residue 1129 type sequence P description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 23) chain A residue 1130 type sequence S description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 24) chain A residue 1131 type sequence V description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 25) chain A residue 1132 type sequence N description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 26) chain A residue 1133 type sequence G description BINDING SITE FOR RESIDUE GOL A 2166 source : AC9 27) chain A residue 978 type sequence E description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 28) chain A residue 979 type sequence H description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 29) chain A residue 982 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 30) chain A residue 983 type sequence G description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 31) chain A residue 989 type sequence F description BINDING SITE FOR RESIDUE GOL A 2167 source : BC1 32) chain A residue 1081 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 1084 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 1089 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 1092 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:O95271 source Swiss-Prot : SWS_FT_FI1

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