eF-site ID 4bkx-B PDB Code 4bkx Chain B click to enlarge Title The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex Classification TRANSCRIPTION Compound METASTASIS-ASSOCIATED PROTEIN MTA1 Source Homo sapiens (Human) (HDAC1_HUMAN) Sequence B:  RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGL YRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY SKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQ QTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYH QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPG TGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSK VMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEF VKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNE LPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLF ENLRMLPHA Description Functional site 1) chain B residue 176 type sequence D description BINDING SITE FOR RESIDUE ZN B 600 source : AC1 2) chain B residue 178 type sequence H description BINDING SITE FOR RESIDUE ZN B 600 source : AC1 3) chain B residue 264 type sequence D description BINDING SITE FOR RESIDUE ZN B 600 source : AC1 4) chain B residue 140 type sequence H description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 5) chain B residue 141 type sequence H description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 6) chain B residue 176 type sequence D description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 7) chain B residue 178 type sequence H description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 8) chain B residue 264 type sequence D description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 9) chain B residue 301 type sequence G description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 10) chain B residue 303 type sequence Y description BINDING SITE FOR RESIDUE ACT B 601 source : AC2 11) chain B residue 174 type sequence D description BINDING SITE FOR RESIDUE K B 602 source : AC3 12) chain B residue 176 type sequence D description BINDING SITE FOR RESIDUE K B 602 source : AC3 13) chain B residue 178 type sequence H description BINDING SITE FOR RESIDUE K B 602 source : AC3 14) chain B residue 197 type sequence S description BINDING SITE FOR RESIDUE K B 602 source : AC3 15) chain B residue 198 type sequence F description BINDING SITE FOR RESIDUE K B 602 source : AC3 16) chain B residue 187 type sequence F description BINDING SITE FOR RESIDUE K B 603 source : AC4 17) chain B residue 190 type sequence T description BINDING SITE FOR RESIDUE K B 603 source : AC4 18) chain B residue 193 type sequence V description BINDING SITE FOR RESIDUE K B 603 source : AC4 19) chain B residue 222 type sequence Y description BINDING SITE FOR RESIDUE K B 603 source : AC4 20) chain B residue 270 type sequence R description BINDING SITE FOR RESIDUE SO4 B 501 source : AC5 21) chain B residue 303 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 501 source : AC5 22) chain B residue 304 type sequence T description BINDING SITE FOR RESIDUE SO4 B 501 source : AC5 23) chain B residue 305 type sequence I description BINDING SITE FOR RESIDUE SO4 B 501 source : AC5 24) chain B residue 306 type sequence R description BINDING SITE FOR RESIDUE SO4 B 501 source : AC5 25) chain B residue 31 type sequence K description BINDING SITE FOR RESIDUE SO4 B 502 source : AC6 26) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE SO4 B 503 source : AC7 27) chain B residue 28 type sequence H description BINDING SITE FOR RESIDUE SO4 B 503 source : AC7 28) chain B residue 31 type sequence K description BINDING SITE FOR RESIDUE SO4 B 503 source : AC7 29) chain B residue 55 type sequence R description BINDING SITE FOR RESIDUE SO4 B 504 source : AC8 30) chain B residue 57 type sequence H description BINDING SITE FOR RESIDUE SO4 B 504 source : AC8 31) chain B residue 58 type sequence K description BINDING SITE FOR RESIDUE SO4 B 504 source : AC8 32) chain B residue 74 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q92769 source Swiss-Prot : SWS_FT_FI11 33) chain B residue 74 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 220 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 261 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P70288 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 273 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P70288 source Swiss-Prot : SWS_FT_FI4 37) chain B residue 141 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:19182791, ECO:0000269|PubMed:28497810 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links