eF-site ID 4bka-AC
PDB Code 4bka
Chain A, C

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Title crystal structure of the human EphA4 ectodomain in complex with human ephrin A5
Classification CELL ADHESION
Compound EPHRIN TYPE-A RECEPTOR 4
Source (EFNA5_HUMAN)
Sequence A:  PANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTP
IRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLR
DCNSLPGVMGTCKETFNLYYYESDNDKERFIRENQFVKID
TIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQ
DVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSL
VEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGH
EERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATS
CTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNL
EWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHY
TPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNP
DQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDR
PNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPL
TSYVFHVRARTAAGYGDFSEPLEVTTN
C:  DRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSV
PEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPN
GPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRR
SCLKLKVFVRPTNSCMK
Description


Functional site
1) chain C
residue 41
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17400922
source Swiss-Prot : SWS_FT_FI1
2) chain A
residue 235
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2
3) chain A
residue 340
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2
4) chain A
residue 408
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2
5) chain C
residue 117-144
type prosite
sequence KFSEKFQLFTPFSLGFEFRPGREYFYIS
description EPHRIN_RBD_1 Ephrin receptor-binding (ephrin RBD) domain signature. KFSeKFQlFTPfslGfEFrpgreYFyiS
source prosite : PS01299
6) chain A
residue 185-205
type prosite
sequence FQDVGACIALVSVRVFYKKCP
description RECEPTOR_TYR_KIN_V_1 Receptor tyrosine kinase class V signature 1. FqDvGACIALVSVRVfykKCP
source prosite : PS00790
7) chain A
residue 247-267
type prosite
sequence CGADGEWLVPIGNCLCNAGHE
description RECEPTOR_TYR_KIN_V_2 Receptor tyrosine kinase class V signature 2. CgaDGEWlv.PIGnClCnaGHE
source prosite : PS00791

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