eF-site ID 4bjh-B PDB Code 4bjh Chain B click to enlarge Title Crystal Structure of the Aquifex Reactor Complex Formed by Dihydroorotase (H180A, H232A) with Dihydroorotate and Aspartate Transcarbamoylase with N-(phosphonacetyl)-L-aspartate (PALA) Classification HYDROLASE/TRANSFERASE Compound DIHYDROOROTASE Source (PYRB_AQUAE) Sequence B:  MRSLISSLDLTREEVEEILKYAKEFKEGKEETIKASAVLF FSEPSTRTRLSFEKAARELGIETYLVSGSESSTVKGESFF DTLKTFEGLGFDYVVFRVPFVFFPYKEIVKSLNLRLVNAG DGTHQHPSQGLIDFFTIKEHFGEVKDLRVLYVGDIKHSRV FRSGAPLLNMFGAKIGVCGPKTLIPRDVEVFKVDVFDDVD KGIDWADVVIWLRLQKERQKENYIPSESSYFKQFGLTKER FEKVKLYMHPGPVNRNVDIDHELVYTEKSLIQEQVKNGIP VRKAIYKFLWT Description Functional site 1) chain B residue 45 type sequence S description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 2) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 3) chain B residue 47 type sequence R description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 4) chain B residue 48 type sequence T description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 5) chain B residue 72 type sequence S description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 6) chain B residue 75 type sequence K description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 7) chain B residue 97 type sequence R description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 8) chain B residue 126 type sequence H description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 9) chain B residue 159 type sequence R description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 10) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 11) chain B residue 213 type sequence R description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 12) chain B residue 215 type sequence Q description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 13) chain B residue 251 type sequence G description BINDING SITE FOR RESIDUE PAL B 292 source : AC3 14) chain B residue 196 type sequence F description BINDING SITE FOR RESIDUE PO4 B 293 source : AC4 15) chain B residue 197 type sequence D description BINDING SITE FOR RESIDUE PO4 B 293 source : AC4 16) chain B residue 198 type sequence D description BINDING SITE FOR RESIDUE PO4 B 293 source : AC4 17) chain B residue 201 type sequence K description BINDING SITE FOR RESIDUE PO4 B 293 source : AC4 18) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 295 source : AC5 19) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 295 source : AC5 20) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 295 source : AC5 21) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 296 source : AC6 22) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 296 source : AC6 23) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE BA B 296 source : AC6 24) chain B residue 9 type sequence D description BINDING SITE FOR RESIDUE BA B 297 source : AC7 25) chain B residue 14 type sequence E description BINDING SITE FOR RESIDUE BA B 297 source : AC7 26) chain B residue 47 type sequence R description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 27) chain B residue 77 type sequence E description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 28) chain B residue 81 type sequence D description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 29) chain B residue 252 type sequence P description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 30) chain B residue 253 type sequence V description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 31) chain B residue 265 type sequence Y description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 32) chain B residue 271 type sequence I description BINDING SITE FOR RESIDUE EDO B 302 source : AC9 33) chain B residue 49 type sequence R description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 34) chain B residue 65 type sequence L description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 35) chain B residue 65 type sequence L description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 36) chain B residue 66 type sequence V description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 37) chain B residue 67 type sequence S description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 38) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 39) chain B residue 70 type sequence E description BINDING SITE FOR RESIDUE EDO B 303 source : BC1 40) chain B residue 43 type sequence E description BINDING SITE FOR RESIDUE EDO B 304 source : BC2 41) chain B residue 99 type sequence P description BINDING SITE FOR RESIDUE EDO B 304 source : BC2 42) chain B residue 217 type sequence E description BINDING SITE FOR RESIDUE EDO B 304 source : BC2 43) chain B residue 218 type sequence R description BINDING SITE FOR RESIDUE EDO B 304 source : BC2 44) chain B residue 195 type sequence V description BINDING SITE FOR RESIDUE EDO B 305 source : BC3 45) chain B residue 3 type sequence S description BINDING SITE FOR RESIDUE EDO B 306 source : BC4 46) chain B residue 9 type sequence D description BINDING SITE FOR RESIDUE EDO B 306 source : BC4 47) chain B residue 288 type sequence F description BINDING SITE FOR RESIDUE EDO B 306 source : BC4 48) chain B residue 12 type sequence R description BINDING SITE FOR RESIDUE EDO B 308 source : BC6 49) chain B residue 13 type sequence E description BINDING SITE FOR RESIDUE EDO B 308 source : BC6 50) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE EDO B 308 source : BC6 51) chain B residue 195 type sequence V description BINDING SITE FOR RESIDUE EDO B 309 source : BC7 52) chain B residue 197 type sequence D description BINDING SITE FOR RESIDUE EDO B 309 source : BC7 53) chain B residue 198 type sequence D description BINDING SITE FOR RESIDUE EDO B 311 source : BC9 54) chain B residue 199 type sequence V description BINDING SITE FOR RESIDUE EDO B 311 source : BC9 55) chain B residue 200 type sequence D description BINDING SITE FOR RESIDUE EDO B 311 source : BC9 56) chain B residue 233 type sequence Q description BINDING SITE FOR RESIDUE EDO B 311 source : BC9 57) chain B residue 240 type sequence R description BINDING SITE FOR RESIDUE EDO B 311 source : BC9 58) chain B residue 6 type sequence S description BINDING SITE FOR RESIDUE EDO B 312 source : CC1 59) chain B residue 8 type sequence L description BINDING SITE FOR RESIDUE EDO B 312 source : CC1 60) chain B residue 105 type sequence Y description BINDING SITE FOR RESIDUE EDO B 312 source : CC1 61) chain B residue 124 type sequence H description BINDING SITE FOR RESIDUE EDO B 312 source : CC1 62) chain B residue 41-48 type prosite sequence FSEPSTRT description CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FsEpSTRT source prosite : PS00097 63) chain B residue 47 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 252 type BINDING sequence P description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 65) chain B residue 48 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 66) chain B residue 75 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 67) chain B residue 97 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 126 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 129 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 70) chain B residue 159 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 213 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 251 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00001 source Swiss-Prot : SWS_FT_FI1

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