eF-site ID 4bcp-D PDB Code 4bcp Chain D click to enlarge Title Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor Classification TRANSFERASE/CELL CYCLE Compound CYCLIN-DEPENDENT KINASE 2 Source Homo sapiens (Human) (CCNA2_HUMAN) Sequence D:  PDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILV DWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRME HLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMF LGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPES LIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKN SKYHGVSLLNPPETLNL Description (1)  CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2 Functional site 1) chain D residue 202 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 2) chain D residue 203 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 3) chain D residue 244 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 4) chain D residue 245 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 5) chain D residue 246 type sequence M description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 6) chain D residue 247 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1433 source : AC5 7) chain D residue 192 type sequence K description BINDING SITE FOR RESIDUE SGM D 1434 source : AC6 8) chain D residue 193 type sequence C description BINDING SITE FOR RESIDUE SGM D 1434 source : AC6 9) chain D residue 241 type sequence R description BINDING SITE FOR RESIDUE SGM D 1434 source : AC6 10) chain D residue 305 type sequence D description BINDING SITE FOR RESIDUE SGM D 1434 source : AC6

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