eF-site ID 4bcn-D PDB Code 4bcn Chain D click to enlarge Title Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor Classification TRANSFERASE/CELL CYCLE Compound CYCLIN-DEPENDENT KINASE 2 Source Homo sapiens (Human) (CCNA2_HUMAN) Sequence D:  DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVD WLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEH LVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFL GELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESL IRKTGYTLESLKPCLLDLHQTYLKAPQHAQQSIREKYKNS KYHGVSLLNPPETLN Description (1)  CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.11.22), CYCLIN-A2 Functional site 1) chain D residue 199 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 2) chain D residue 202 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 3) chain D residue 203 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 4) chain D residue 243 type sequence L description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 5) chain D residue 244 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 6) chain D residue 245 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 7) chain D residue 246 type sequence M description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 8) chain D residue 247 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1432 source : AC4 9) chain D residue 211-242 type prosite sequence RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF description CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF source prosite : PS00292

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