eF-site ID 4bbn-ACF PDB Code 4bbn Chain A, C, F click to enlarge Title NEDD4 HECT-Ub:Ub complex Classification LIGASE/SIGNALING PROTEIN Compound E3 UBIQUITIN-PROTEIN LIGASE NEDD4 Source Homo sapiens (Human) (UBB_BOVIN) Sequence A:  GSRDYKRKYEFFRRKLKKQNDIPNKFEMKLRRATVLEDSY RRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLIS KEMFNPYYGLFEYSATDNYTLQINPNSGINPDHLSYFKFI GRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVD SEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNG GSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFE LIPQDLIKIFDENELELLMSGLGDVDVNDWREHTKYKNGY SANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGF AELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYES FEELWDKLQMAIENTQGF C:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG F:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGC Description Functional site 1) chain C residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 2) chain C residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214 source Swiss-Prot : SWS_FT_FI6 3) chain C residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI4 4) chain C residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:26116755 source Swiss-Prot : SWS_FT_FI3 5) chain C residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 6) chain C residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 7) chain C residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 8) chain C residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 9) chain C residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 10) chain C residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 11) chain C residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 12) chain C residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 13) chain C residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG47 source Swiss-Prot : SWS_FT_FI5 14) chain C residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 15) chain F residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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