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eF-site ID
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4bao-B |
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PDB Code
|
4bao |
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Chain
|
B |
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click to enlarge
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Title
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Thrombin in complex with inhibitor |
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Classification
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HYDROLASE |
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Compound
|
THROMBIN LIGHT CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
|
B: |
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLT
AAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM
LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL
PDRETAASLLQAGYKGRVTGWGNLKETWGQPSVLQVVNLP
IVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRL
KKWIQKVIDQF
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Description
|
(1) |
THROMBIN LIGHT CHAIN (E.C.3.4.21.5), THROMBIN HEAVY CHAIN (E.C.3.4.21.5), HIRUDIN VARIANT-2
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Functional site
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1)
|
chain |
B |
| residue |
75-80 |
| type |
prosite |
| sequence |
LTAAHC
|
| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
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|
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2)
|
chain |
B |
| residue |
229-240 |
| type |
prosite |
| sequence |
DACEGDSGGPFV
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| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
|
| source |
prosite : PS00135
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3)
|
chain |
B |
| residue |
135 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:3513162
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
B |
| residue |
235 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Sulfotyrosine => ECO:0000269|PubMed:3513162
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
89 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923
|
| source |
Swiss-Prot : SWS_FT_FI2
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