eF-site ID 4ayx-A PDB Code 4ayx Chain A click to enlarge Title STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B) Classification MEMBRANE PROTEIN Compound ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 Source Homo sapiens (Human) (ABCBA_HUMAN) Sequence A:  LPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLG KIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRV YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELIN RLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPN LATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQL AEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAF ARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSS FLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREP KLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDF SLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL DGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGAD DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQ EALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYG KHEELLSKPNG Description Functional site 1) chain A residue 534 type sequence S description BINDING SITE FOR RESIDUE MG A 801 source : AC1 2) chain A residue 575 type sequence Q description BINDING SITE FOR RESIDUE MG A 801 source : AC1 3) chain A residue 658 type sequence D description BINDING SITE FOR RESIDUE MG A 801 source : AC1 4) chain A residue 501 type sequence Y description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 5) chain A residue 509 type sequence I description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 6) chain A residue 529 type sequence S description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 7) chain A residue 530 type sequence G description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 8) chain A residue 531 type sequence S description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 9) chain A residue 532 type sequence G description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 10) chain A residue 533 type sequence K description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 11) chain A residue 534 type sequence S description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 12) chain A residue 535 type sequence T description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 13) chain A residue 575 type sequence Q description BINDING SITE FOR RESIDUE ACP A 900 source : AC2 14) chain A residue 170 type sequence R description BINDING SITE FOR RESIDUE GLY A 1717 source : AC3 15) chain A residue 234 type sequence Y description BINDING SITE FOR RESIDUE GLY A 1717 source : AC3 16) chain A residue 242 type sequence R description BINDING SITE FOR RESIDUE GLY A 1717 source : AC3 17) chain A residue 197 type sequence D description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 18) chain A residue 200 type sequence Y description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 19) chain A residue 201 type sequence T description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 20) chain A residue 218 type sequence L description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 21) chain A residue 421 type sequence M description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 22) chain A residue 422 type sequence G description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 23) chain A residue 427 type sequence T description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 24) chain A residue 428 type sequence V description BINDING SITE FOR RESIDUE LMT A 1720 source : AC4 25) chain A residue 313 type sequence N description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 26) chain A residue 313 type sequence N description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 27) chain A residue 316 type sequence T description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 28) chain A residue 316 type sequence T description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 29) chain A residue 317 type sequence F description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 30) chain A residue 317 type sequence F description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 31) chain A residue 405 type sequence S description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 32) chain A residue 405 type sequence S description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 33) chain A residue 416 type sequence K description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 34) chain A residue 416 type sequence K description BINDING SITE FOR RESIDUE CDL A 1721 source : AC5 35) chain A residue 405 type sequence S description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 36) chain A residue 409 type sequence I description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 37) chain A residue 412 type sequence S description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 38) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 39) chain A residue 416 type sequence K description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 40) chain A residue 420 type sequence L description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 41) chain A residue 423 type sequence S description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 42) chain A residue 425 type sequence H description BINDING SITE FOR RESIDUE LMT A 1724 source : AC6 43) chain A residue 184 type sequence I description BINDING SITE FOR RESIDUE CDL A 1726 source : AC7 44) chain A residue 229 type sequence N description BINDING SITE FOR RESIDUE CDL A 1726 source : AC7 45) chain A residue 407 type sequence N description BINDING SITE FOR RESIDUE CDL A 1726 source : AC7 46) chain A residue 527 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI4 47) chain A residue 237-312 type TOPO_DOM sequence QTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLS SDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSP description Mitochondrial intermembrane => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 48) chain A residue 429-430 type TOPO_DOM sequence GE description Mitochondrial intermembrane => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 49) chain A residue 265 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI5 50) chain A residue 582 type MOD_RES sequence C description S-glutathionyl cysteine => ECO:0000250|UniProtKB:Q9JI39 source Swiss-Prot : SWS_FT_FI6 51) chain A residue 171-191 type TRANSMEM sequence LAAAVGFLTMSSVISMSAPFF description Helical => ECO:0000255|PROSITE-ProRule:PRU00441 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 216-236 type TRANSMEM sequence LGLSAVFLCGAAANAIRVYLM description Helical => ECO:0000255|PROSITE-ProRule:PRU00441 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 313-333 type TRANSMEM sequence NLATFVLSVVPPVSIIAVIYG description Helical => ECO:0000255|PROSITE-ProRule:PRU00441 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 408-428 type TRANSMEM sequence LIVLSVLYKGGLLMGSAHMTV description Helical => ECO:0000255|PROSITE-ProRule:PRU00441 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 431-451 type TRANSMEM sequence LSSFLMYAFWVGISIGGLSSF description Helical => ECO:0000255|PROSITE-ProRule:PRU00441 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 192-215 type TOPO_DOM sequence LGKIIDVIYTNPTVDYSDNLTRLC description Mitochondrial matrix => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 334-407 type TOPO_DOM sequence RYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTE IEKYASKVDHVMQLARKEAFARAGFFGATGLSGN description Mitochondrial matrix => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 634-648 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211

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