eF-site ID 4ax7-B
PDB Code 4ax7
Chain B

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Title Hypocrea jecorina Cel6A D221A mutant soaked with 4-Methylumbelliferyl- beta-D-cellobioside
Classification HYDROLASE
Compound EXOGLUCANASE 2
Source (GUX2_HYPJE)
Sequence B:  TATYSGNPFVGVTPWANAYYASEVSSLAIPSLTGAMATAA
AAVAKVPSFMWLDTLDKTPLMEQTLADIRTANKNGGNYAG
QFVVYDLPDRDCAANGEYSIADGGVAKYKNYIDTIRQIVV
EYSDIRTLLVIEPASLANLVTNLGTPKCANAQSAYLECIN
YAVTQLNLPNVAMYLDAGHAGWLGWPANQDPAAQLFANVY
KNASSPRALRGLATNVANYNGWNITSPPSYTQGNAVYNEK
LYIHAIGPLLANHGWSNAFFITDQGRSGKQPTGQQQWGDW
CNVIGTGFGIRPSANTGDSLLDSFVWVKPGGECDGTSDSS
APRFDSHCALPDALQPAPQAGAWFQAYFVQLLTNANPSFL
Description


Functional site
1) chain B
residue 221
type ACT_SITE
sequence A
description Proton donor => ECO:0000269|PubMed:12188666
source Swiss-Prot : SWS_FT_FI1
2) chain B
residue 175
type SITE
sequence D
description Transition state stabilizer that also modulates the pKa of Asp-245 and may act as a proton acceptor through a water chain => ECO:0000269|PubMed:2377893
source Swiss-Prot : SWS_FT_FI2
3) chain B
residue 87
type CARBOHYD
sequence T
description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI3
4) chain B
residue 97
type CARBOHYD
sequence T
description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI3
5) chain B
residue 122
type CARBOHYD
sequence T
description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI3
6) chain B
residue 106
type CARBOHYD
sequence S
description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI4
7) chain B
residue 109
type CARBOHYD
sequence S
description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI4
8) chain B
residue 110
type CARBOHYD
sequence S
description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI4
9) chain B
residue 115
type CARBOHYD
sequence S
description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI4
10) chain B
residue 289
type CARBOHYD
sequence N
description N-linked (GlcNAc) asparagine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI5
11) chain B
residue 310
type CARBOHYD
sequence N
description N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646
source Swiss-Prot : SWS_FT_FI6
12) chain B
residue 169
type catalytic
sequence Y
description 440
source MCSA : MCSA2
13) chain B
residue 174
type catalytic
sequence R
description 440
source MCSA : MCSA2
14) chain B
residue 175
type catalytic
sequence D
description 440
source MCSA : MCSA2
15) chain B
residue 221
type catalytic
sequence A
description 440
source MCSA : MCSA2
16) chain B
residue 401
type catalytic
sequence D
description 440
source MCSA : MCSA2

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