eF-site ID 4ax6-B PDB Code 4ax6 Chain B click to enlarge Title HYPOCREA JECORINA CEL6A D221A MUTANT SOAKED WITH 6-CHLORO-4- PHENYLUMBELLIFERYL-BETA-CELLOBIOSIDE Classification HYDROLASE Compound EXOGLUCANASE 2 Source Hypocrea jecorina (Trichoderma reesei) (GUX2_HYPJE) Sequence B:  TATYSGNPFVGVTPWANAYYASEVSSLAIPSLTGAMATAA AAVAKVPSFMWLDTLDKTPLMEQTLADIRTANKNGGNYAG QFVVYDLPDRDCAALASNGEYSIADGGVAKYKNYIDTIRQ IVVEYSDIRTLLVIEPASLANLVTNLGTPKCANAQSAYLE CINYAVTQLNLPNVAMYLDAGHAGWLGWPANQDPAAQLFA NVYKNASSPRALRGLATNVANYNGWNITSPPSYTQGNAVY NEKLYIHAIGPLLANHGWSNAFFITDQGRSGKQPTGQQQW GDWCNVIGTGFGIRPSANTGDSLLDSFVWVKPGGECDGTS DSSAPRFDSHCALPDALQPAPQAGAWFQAYFVQLLTNANP SFL Description Functional site 1) chain B residue 169 type catalytic sequence Y description 440 source MCSA : MCSA2 2) chain B residue 174 type catalytic sequence R description 440 source MCSA : MCSA2 3) chain B residue 175 type catalytic sequence D description 440 source MCSA : MCSA2 4) chain B residue 181 type catalytic sequence S description 440 source MCSA : MCSA2 5) chain B residue 221 type catalytic sequence A description 440 source MCSA : MCSA2 6) chain B residue 401 type catalytic sequence D description 440 source MCSA : MCSA2 7) chain B residue 221 type ACT_SITE sequence A description Proton donor => ECO:0000269|PubMed:12188666 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 175 type SITE sequence D description Transition state stabilizer that also modulates the pKa of Asp-245 and may act as a proton acceptor through a water chain => ECO:0000269|PubMed:2377893 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 87 type CARBOHYD sequence T description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 97 type CARBOHYD sequence T description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 122 type CARBOHYD sequence T description O-linked (Man...) threonine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 106 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI4 13) chain B residue 109 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI4 14) chain B residue 110 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI4 15) chain B residue 115 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI4 16) chain B residue 289 type CARBOHYD sequence N description N-linked (GlcNAc) asparagine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI5 17) chain B residue 310 type CARBOHYD sequence N description N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000269|PubMed:12188666, ECO:0000269|PubMed:8875646 source Swiss-Prot : SWS_FT_FI6

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