eF-site ID 4aw6-E PDB Code 4aw6 Chain E click to enlarge Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) Classification HYDROLASE Compound CAAX PRENYL PROTEASE 1 HOMOLOG Source Homo sapiens (Human) (FACE1_HUMAN) Sequence E:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKT Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84) Functional site 1) chain E residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 2) chain E residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 3) chain E residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 4) chain E residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 5) chain E residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 E 1473 source : AC8 6) chain E residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 7) chain E residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 8) chain E residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 9) chain E residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 10) chain E residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain E residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain E residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain E residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 14) chain E residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 15) chain E residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 16) chain E residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 17) chain E residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 18) chain E residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 19) chain E residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain E residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 21) chain E residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 22) chain E residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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