eF-site ID 4aw6-D
PDB Code 4aw6
Chain D

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Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)
Classification HYDROLASE
Compound CAAX PRENYL PROTEASE 1 HOMOLOG
Source Homo sapiens (Human) (FACE1_HUMAN)
Sequence D:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT
HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG
TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA
GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI
LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD
YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG
SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL
GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF
AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR
FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS
MWHYSHPPLLERLQALKT
Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84)


Functional site

1) chain D
residue 335
type
ligand
sequence H
description BINDING SITE FOR RESIDUE ZN D 1472
source : AC5

2) chain D
residue 336
type
ligand
sequence E
description BINDING SITE FOR RESIDUE ZN D 1472
source : AC5

3) chain D
residue 339
type
ligand
sequence H
description BINDING SITE FOR RESIDUE ZN D 1472
source : AC5

4) chain D
residue 415
type
ligand
sequence E
description BINDING SITE FOR RESIDUE ZN D 1472
source : AC5

5) chain D
residue 271
type
ligand
sequence F
description BINDING SITE FOR RESIDUE PC1 D 1473
source : AC6

6) chain D
residue 336
type ACT_SITE
ligand
sequence E
description {ECO:0000269|PubMed:23539603}.
source Swiss-Prot : SWS_FT_FI9

7) chain D
residue 419
type ACT_SITE
ligand
sequence D
description Proton donor. {ECO:0000250}.
source Swiss-Prot : SWS_FT_FI10

8) chain D
residue 335
type METAL
ligand
sequence H
description Zinc; catalytic
source Swiss-Prot : SWS_FT_FI11

9) chain D
residue 339
type METAL
ligand
sequence H
description Zinc; catalytic
source Swiss-Prot : SWS_FT_FI11

10) chain D
residue 415
type METAL
ligand
sequence E
description Zinc; catalytic
source Swiss-Prot : SWS_FT_FI11

11) chain D
residue 19-39
type TRANSMEM
ligand
sequence IFGAVLLFSWTVYLWETFLAQ
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

12) chain D
residue 82-102
type TRANSMEM
ligand
sequence GLYSETEGTLILLFGGIPYLW
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

13) chain D
residue 124-144
type TRANSMEM
ligand
sequence LVFLLLATLFSALAGLPWSLY
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

14) chain D
residue 171-191
type TRANSMEM
ligand
sequence FVVTQCILLPVSSLLLYIIKI
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

15) chain D
residue 196-216
type TRANSMEM
ligand
sequence FFIYAWLFTLVVSLVLVTIYA
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

16) chain D
residue 348-368
type TRANSMEM
ligand
sequence NIIISQMNSFLCFFLFAVLIG
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12

17) chain D
residue 383-405
type TRANSMEM
ligand
sequence PTLIGLLIIFQFIFSPYNEVLSF
description Helical. {ECO:0000255}.
source Swiss-Prot : SWS_FT_FI12


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