eF-site ID 4aw6-D PDB Code 4aw6 Chain D click to enlarge Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) Classification HYDROLASE Compound CAAX PRENYL PROTEASE 1 HOMOLOG Source Homo sapiens (Human) (FACE1_HUMAN) Sequence D:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKT Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84) Functional site 1) chain D residue 335 type ligand sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 2) chain D residue 336 type ligand sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 3) chain D residue 339 type ligand sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 4) chain D residue 415 type ligand sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 5) chain D residue 271 type ligand sequence F description BINDING SITE FOR RESIDUE PC1 D 1473 source : AC6 6) chain D residue 336 type ACT_SITE ligand sequence E description {ECO:0000269|PubMed:23539603}. source Swiss-Prot : SWS_FT_FI9 7) chain D residue 419 type ACT_SITE ligand sequence D description Proton donor. {ECO:0000250}. source Swiss-Prot : SWS_FT_FI10 8) chain D residue 335 type METAL ligand sequence H description Zinc; catalytic source Swiss-Prot : SWS_FT_FI11 9) chain D residue 339 type METAL ligand sequence H description Zinc; catalytic source Swiss-Prot : SWS_FT_FI11 10) chain D residue 415 type METAL ligand sequence E description Zinc; catalytic source Swiss-Prot : SWS_FT_FI11 11) chain D residue 19-39 type TRANSMEM ligand sequence IFGAVLLFSWTVYLWETFLAQ description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 12) chain D residue 82-102 type TRANSMEM ligand sequence GLYSETEGTLILLFGGIPYLW description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 13) chain D residue 124-144 type TRANSMEM ligand sequence LVFLLLATLFSALAGLPWSLY description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 14) chain D residue 171-191 type TRANSMEM ligand sequence FVVTQCILLPVSSLLLYIIKI description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 15) chain D residue 196-216 type TRANSMEM ligand sequence FFIYAWLFTLVVSLVLVTIYA description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 16) chain D residue 348-368 type TRANSMEM ligand sequence NIIISQMNSFLCFFLFAVLIG description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12 17) chain D residue 383-405 type TRANSMEM ligand sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical. {ECO:0000255}. source Swiss-Prot : SWS_FT_FI12

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