eF-site ID 4aw6-D PDB Code 4aw6 Chain D click to enlarge Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) Classification HYDROLASE Compound CAAX PRENYL PROTEASE 1 HOMOLOG Source Homo sapiens (Human) (FACE1_HUMAN) Sequence D:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKT Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84) Functional site 1) chain D residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 2) chain D residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 3) chain D residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 4) chain D residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 5) chain D residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 D 1473 source : AC6 6) chain D residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 10) chain D residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 13) chain D residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 15) chain D residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 16) chain D residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 17) chain D residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 18) chain D residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 19) chain D residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 20) chain D residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 21) chain D residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 22) chain D residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5

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