eF-site ID 4aw6-ABDE PDB Code 4aw6 Chain A, B, D, E click to enlarge Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1) Classification HYDROLASE Compound CAAX PRENYL PROTEASE 1 HOMOLOG Source Homo sapiens (Human) (FACE1_HUMAN) Sequence A:  GMWASLDALWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQ RRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWS GLYSETEGTLILLFGGIPYLWRLSGRPEYEITQSLVFLLL ATLFSALAGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIK KFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSL VLVTIYADYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPL TKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCK NEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAV LIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSF CLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGF PVSDWLFSMWHYSHPPLLERLQALKTM B:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKTM D:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKT E:  LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTT HVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEG TLILLFGGIPYLWRLSGRPEYEITQSLVFLLLATLFSALA GLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCI LLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYAD YIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEG SKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAVL GHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELF AAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRR FEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFS MWHYSHPPLLERLQALKT Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84) Functional site 1) chain A residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN A 1473 source : AC1 2) chain A residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN A 1473 source : AC1 3) chain A residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN A 1473 source : AC1 4) chain A residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN A 1473 source : AC1 5) chain A residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 A 1474 source : AC2 6) chain B residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN B 1473 source : AC3 7) chain B residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN B 1473 source : AC3 8) chain B residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN B 1473 source : AC3 9) chain B residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN B 1473 source : AC3 10) chain B residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 B 1474 source : AC4 11) chain D residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 12) chain D residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 13) chain D residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 14) chain D residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN D 1472 source : AC5 15) chain D residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 D 1473 source : AC6 16) chain E residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 17) chain E residue 336 type sequence E description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 18) chain E residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 19) chain E residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN E 1472 source : AC7 20) chain E residue 271 type sequence F description BINDING SITE FOR RESIDUE PC1 E 1473 source : AC8 21) chain A residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 30) chain E residue 103-123 type TOPO_DOM sequence RLSGRPEYEITQS description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 31) chain E residue 192-195 type TOPO_DOM sequence GGDY description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 32) chain E residue 369-382 type TOPO_DOM sequence RKELFAAFGFYDSQ description Lumenal => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 38) chain A residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 44) chain B residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 45) chain B residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 46) chain B residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 47) chain D residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 48) chain D residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 49) chain D residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 50) chain D residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 51) chain D residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 52) chain D residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 53) chain D residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 54) chain E residue 19-39 type TRANSMEM sequence IFGAVLLFSWTVYLWETFLAQ description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 55) chain E residue 82-102 type TRANSMEM sequence GLYSETEGTLILLFGGIPYLW description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 56) chain E residue 124-144 type TRANSMEM sequence LVFLLLATLFSALAGLPWSLY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 57) chain E residue 171-191 type TRANSMEM sequence FVVTQCILLPVSSLLLYIIKI description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 58) chain E residue 196-216 type TRANSMEM sequence FFIYAWLFTLVVSLVLVTIYA description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 59) chain E residue 348-368 type TRANSMEM sequence NIIISQMNSFLCFFLFAVLIG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 60) chain E residue 383-405 type TRANSMEM sequence PTLIGLLIIFQFIFSPYNEVLSF description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 61) chain A residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 63) chain A residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 64) chain B residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 65) chain B residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 66) chain B residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 67) chain D residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 68) chain D residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 69) chain D residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 70) chain E residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 71) chain E residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 72) chain E residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFFKNKRIVLFDTLLEQGCKNEEVLAV LGHELGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 73) chain A residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 74) chain B residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 75) chain D residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 76) chain E residue 336 type ACT_SITE sequence E description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 77) chain B residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 78) chain B residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 79) chain D residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 80) chain D residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 81) chain D residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 82) chain E residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 83) chain E residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 84) chain E residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 85) chain A residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 86) chain A residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 87) chain B residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 88) chain A residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5

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