eF-site ID 4ajx-ABCDEFGHIJKL PDB Code 4ajx Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin Classification HORMONE Compound INSULIN Source Homo sapiens (Human) (INS_HUMAN) Sequence A:  GIVEQCCTSICSLYQLENYCN B:  FVNQHLCGSHLVEALYLVCGERGFFYTPK C:  GIVEQCCTSICSLYQLENYCN D:  FVNQHLCGSHLVEALYLVCGERGFFYTP E:  GIVEQCCTSICSLYQLENYCN F:  FVNQHLCGSHLVEALYLVCGERGFFYTP G:  GIVEQCCTSICSLYQLENYCN H:  FVNQHLCGSHLVEALYLVCGERGFFYTPK I:  GIVEQCCTSICSLYQLENYCN J:  FVNQHLCGSHLVEALYLVCGERGFFYTP K:  GIVEQCCTSICSLYQLENYCN L:  FVNQHLCGSHLVEALYLVCGERGFFYTPK Description Functional site 1) chain A residue 15 type sequence Q description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 2) chain A residue 18 type sequence N description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 3) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 4) chain C residue 14 type sequence Y description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 5) chain C residue 17 type sequence E description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 6) chain D residue 18 type sequence V description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 7) chain D residue 20 type sequence G description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 8) chain D residue 21 type sequence E description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 9) chain D residue 22 type sequence R description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 10) chain E residue 14 type sequence Y description BINDING SITE FOR RESIDUE 16E A 1022 source : AC1 11) chain A residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 12) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 13) chain A residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 14) chain B residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 15) chain B residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 16) chain F residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO B 1030 source : AC2 17) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE NA B 1031 source : AC3 18) chain D residue 22 type sequence R description BINDING SITE FOR RESIDUE NA B 1031 source : AC3 19) chain C residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 20) chain C residue 9 type sequence S description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 21) chain C residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 22) chain C residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 23) chain D residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 24) chain D residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 25) chain J residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO D 1029 source : AC4 26) chain D residue 13 type sequence E description BINDING SITE FOR RESIDUE IMD D 1030 source : AC5 27) chain H residue 13 type sequence E description BINDING SITE FOR RESIDUE IMD D 1030 source : AC5 28) chain J residue 13 type sequence E description BINDING SITE FOR RESIDUE IMD D 1030 source : AC5 29) chain L residue 13 type sequence E description BINDING SITE FOR RESIDUE IMD D 1030 source : AC5 30) chain D residue 17 type sequence L description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 31) chain E residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 32) chain E residue 9 type sequence S description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 33) chain E residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 34) chain E residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 35) chain F residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 36) chain L residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO E 1022 source : AC6 37) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 1029 source : AC7 38) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 1029 source : AC7 39) chain L residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN F 1029 source : AC7 40) chain D residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 41) chain G residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 42) chain G residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 43) chain G residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 44) chain H residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 45) chain L residue 17 type sequence L description BINDING SITE FOR RESIDUE RCO G 1022 source : AC8 46) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 1030 source : AC9 47) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 1030 source : AC9 48) chain J residue 10 type sequence H description BINDING SITE FOR RESIDUE ZN H 1030 source : AC9 49) chain D residue 3 type sequence N description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 50) chain D residue 6 type sequence L description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 51) chain D residue 10 type sequence H description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 52) chain G residue 3 type sequence V description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 53) chain G residue 4 type sequence E description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 54) chain G residue 7 type sequence C description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 55) chain H residue 3 type sequence N description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 56) chain H residue 4 type sequence Q description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 57) chain H residue 10 type sequence H description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 58) chain J residue 6 type sequence L description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 59) chain J residue 10 type sequence H description BINDING SITE FOR RESIDUE 16E H 1031 source : BC1 60) chain B residue 9 type sequence S description BINDING SITE FOR RESIDUE NA H 1032 source : BC2 61) chain H residue 13 type sequence E description BINDING SITE FOR RESIDUE NA H 1032 source : BC2 62) chain H residue 16 type sequence Y description BINDING SITE FOR RESIDUE NA H 1032 source : BC2 63) chain H residue 17 type sequence L description BINDING SITE FOR RESIDUE NA H 1032 source : BC2 64) chain L residue 13 type sequence E description BINDING SITE FOR RESIDUE NA H 1032 source : BC2 65) chain H residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 66) chain I residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 67) chain I residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 68) chain I residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 69) chain J residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 70) chain J residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO J 1029 source : BC3 71) chain K residue 5 type sequence Q description BINDING SITE FOR RESIDUE IMD K 1022 source : BC4 72) chain K residue 11 type sequence C description BINDING SITE FOR RESIDUE IMD K 1022 source : BC4 73) chain K residue 19 type sequence Y description BINDING SITE FOR RESIDUE IMD K 1022 source : BC4 74) chain B residue 5 type sequence H description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 75) chain K residue 6 type sequence C description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 76) chain K residue 10 type sequence I description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 77) chain K residue 11 type sequence C description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 78) chain L residue 11 type sequence L description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 79) chain L residue 14 type sequence A description BINDING SITE FOR RESIDUE RCO L 1030 source : BC5 80) chain B residue 10 type sequence H description BINDING SITE FOR RESIDUE IMD L 1031 source : BC6 81) chain F residue 6 type sequence L description BINDING SITE FOR RESIDUE IMD L 1031 source : BC6 82) chain F residue 10 type sequence H description BINDING SITE FOR RESIDUE IMD L 1031 source : BC6 83) chain L residue 6 type sequence L description BINDING SITE FOR RESIDUE IMD L 1031 source : BC6 84) chain L residue 10 type sequence H description BINDING SITE FOR RESIDUE IMD L 1031 source : BC6 85) chain A residue 6-20 type prosite sequence CCTSICSLYQLENYC description INSULIN Insulin family signature. CCTSiCSlyqLenyC source prosite : PS00262

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