eF-site ID 4ai8-A PDB Code 4ai8 Chain A click to enlarge Title FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE Classification OXIDOREDUCTASE Compound HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR Source (HIF1N_HUMAN) Sequence A:  SGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDP RAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDF SVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVE KLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWI NKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQI KGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYE RFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGIT ITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEAL GNPQEVGPLLNTMIKGRYN Description Functional site 1) chain A residue 311 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1350 source : AC1 2) chain A residue 312 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1350 source : AC1 3) chain A residue 224 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1351 source : AC2 4) chain A residue 225 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1351 source : AC2 5) chain A residue 315 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1351 source : AC2 6) chain A residue 107 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC3 7) chain A residue 320 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC3 8) chain A residue 324 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC3 9) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC4 10) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC4 11) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC4 12) chain A residue 285 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC4 13) chain A residue 286 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC4 14) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC5 15) chain A residue 141 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC5 16) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC5 17) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1355 source : AC6 18) chain A residue 147 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1355 source : AC6 19) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE GOL A 1355 source : AC6 20) chain A residue 99 type sequence K description BINDING SITE FOR RESIDUE GOL A 1356 source : AC7 21) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1356 source : AC7 22) chain A residue 240 type sequence S description BINDING SITE FOR RESIDUE GOL A 1356 source : AC7 23) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1356 source : AC7 24) chain A residue 243 type sequence D description BINDING SITE FOR RESIDUE GOL A 1356 source : AC7 25) chain A residue 71 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1357 source : AC8 26) chain A residue 75 type sequence K description BINDING SITE FOR RESIDUE GOL A 1357 source : AC8 27) chain A residue 257 type sequence N description BINDING SITE FOR RESIDUE GOL A 1357 source : AC8 28) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 29) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 30) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 31) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 32) chain A residue 205 type sequence N description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 33) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 34) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 35) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 36) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 37) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE DZA A 1358 source : AC9 38) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE ZN A 1359 source : BC1 39) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE ZN A 1359 source : BC1 40) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE ZN A 1359 source : BC1 41) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 214 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 145 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 181 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 300 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 152 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 199 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 52) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 53) chain A residue 279 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 54) chain A residue 340 type SITE sequence L description Important for dimer formation source Swiss-Prot : SWS_FT_FI4

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