eF-site ID 4aa6-ABEF PDB Code 4aa6 Chain A, B, E, F click to enlarge Title The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation Classification TRANSCRIPTION/DNA Compound ESTROGEN RECEPTOR Source (4AA6) Sequence A:  TRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIHNDYMCPA TNQCTIDKNRRKSCQACRLRKCYEVGMMK B:  TRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHDYMCP ATNQCTIDKNRRKSCQACRLRKCYEVGMMK E:  RYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGDYMCPAT NQCTIDKNRRKSCQACRLRKCYEVGMMK F:  TRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMC PATNQCTIDKRKSCQACRLRKCYEVGMMK Description Functional site 1) chain A residue 185 type sequence C description BINDING SITE FOR RESIDUE ZN A 253 source : AC1 2) chain A residue 188 type sequence C description BINDING SITE FOR RESIDUE ZN A 253 source : AC1 3) chain A residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN A 253 source : AC1 4) chain A residue 205 type sequence C description BINDING SITE FOR RESIDUE ZN A 253 source : AC1 5) chain A residue 221 type sequence C description BINDING SITE FOR RESIDUE ZN A 254 source : AC2 6) chain A residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN A 254 source : AC2 7) chain A residue 237 type sequence C description BINDING SITE FOR RESIDUE ZN A 254 source : AC2 8) chain A residue 240 type sequence C description BINDING SITE FOR RESIDUE ZN A 254 source : AC2 9) chain B residue 185 type sequence C description BINDING SITE FOR RESIDUE ZN B 253 source : AC3 10) chain B residue 188 type sequence C description BINDING SITE FOR RESIDUE ZN B 253 source : AC3 11) chain B residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN B 253 source : AC3 12) chain B residue 205 type sequence C description BINDING SITE FOR RESIDUE ZN B 253 source : AC3 13) chain B residue 221 type sequence C description BINDING SITE FOR RESIDUE ZN B 254 source : AC4 14) chain B residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN B 254 source : AC4 15) chain B residue 237 type sequence C description BINDING SITE FOR RESIDUE ZN B 254 source : AC4 16) chain B residue 240 type sequence C description BINDING SITE FOR RESIDUE ZN B 254 source : AC4 17) chain E residue 185 type sequence C description BINDING SITE FOR RESIDUE ZN E 253 source : AC5 18) chain E residue 188 type sequence C description BINDING SITE FOR RESIDUE ZN E 253 source : AC5 19) chain E residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN E 253 source : AC5 20) chain E residue 205 type sequence C description BINDING SITE FOR RESIDUE ZN E 253 source : AC5 21) chain E residue 221 type sequence C description BINDING SITE FOR RESIDUE ZN E 254 source : AC6 22) chain E residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN E 254 source : AC6 23) chain E residue 237 type sequence C description BINDING SITE FOR RESIDUE ZN E 254 source : AC6 24) chain E residue 240 type sequence C description BINDING SITE FOR RESIDUE ZN E 254 source : AC6 25) chain F residue 185 type sequence C description BINDING SITE FOR RESIDUE ZN F 253 source : AC7 26) chain F residue 188 type sequence C description BINDING SITE FOR RESIDUE ZN F 253 source : AC7 27) chain F residue 202 type sequence C description BINDING SITE FOR RESIDUE ZN F 253 source : AC7 28) chain F residue 205 type sequence C description BINDING SITE FOR RESIDUE ZN F 253 source : AC7 29) chain F residue 221 type sequence C description BINDING SITE FOR RESIDUE ZN F 254 source : AC8 30) chain F residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN F 254 source : AC8 31) chain F residue 237 type sequence C description BINDING SITE FOR RESIDUE ZN F 254 source : AC8 32) chain F residue 240 type sequence C description BINDING SITE FOR RESIDUE ZN F 254 source : AC8 33) chain A residue 185-211 type prosite sequence CAVCNDYASGYHYGVWSCEGCKAFFKR description NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CavCn.Dyasgy.HYgvwsCegCkaFFkR source prosite : PS00031 34) chain A residue 185-250 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIHNDYMCPATNQ CTIDKNRRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 185-250 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHDYMCPATN QCTIDKNRRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 36) chain E residue 185-250 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGDYMCPATNQ CTIDKNRRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 37) chain F residue 185-250 type DNA_BIND sequence CAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPAT NQCTIDKRKSCQACRLRKCYEVGM description Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 185-205 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 39) chain A residue 221-245 type ZN_FING sequence CPATNQCTIDKNRRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 185-205 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 221-245 type ZN_FING sequence CPATNQCTIDKNRRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 42) chain E residue 185-205 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 43) chain E residue 221-245 type ZN_FING sequence CPATNQCTIDKNRRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 44) chain F residue 185-205 type ZN_FING sequence CAVCNDYASGYHYGVWSCEGC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2 45) chain F residue 221-245 type ZN_FING sequence CPATNQCTIDKRKSCQACRLRKC description NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 source Swiss-Prot : SWS_FT_FI2

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