eF-site ID 4a69-ABCD PDB Code 4a69 Chain A, B, C, D click to enlarge Title Structure of HDAC3 bound to corepressor and inositol tetraphosphate Classification TRANSCRIPTION Compound HISTONE DEACETYLASE 3, Source null (NCOR2_HUMAN) Sequence A:  AKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGL YKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF TKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNK ICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYH PRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFP GTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVIN QVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVE YVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISE ELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQT IFENLKMLN B:  AKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGL YKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF TKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNK ICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYH PRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFP GTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVIN QVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVE YVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISE ELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQT IFENLKMLN C:  KFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQH PKNFGLIASFLERKTVAECVLYYYLTKKN D:  KFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQH PKNFGLIASFLERKTVAECVLYYYLTKK Description Functional site 1) chain A residue 170 type sequence D description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 2) chain A residue 172 type sequence H description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 3) chain A residue 259 type sequence D description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 4) chain A residue 134 type sequence H description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 5) chain A residue 135 type sequence H description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 6) chain A residue 143 type sequence G description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 7) chain A residue 170 type sequence D description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 8) chain A residue 172 type sequence H description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 9) chain A residue 259 type sequence D description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 10) chain A residue 296 type sequence G description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 11) chain A residue 298 type sequence Y description BINDING SITE FOR RESIDUE ACT A 501 source : AC2 12) chain A residue 168 type sequence D description BINDING SITE FOR RESIDUE K A 503 source : AC3 13) chain A residue 170 type sequence D description BINDING SITE FOR RESIDUE K A 503 source : AC3 14) chain A residue 172 type sequence H description BINDING SITE FOR RESIDUE K A 503 source : AC3 15) chain A residue 191 type sequence S description BINDING SITE FOR RESIDUE K A 503 source : AC3 16) chain A residue 192 type sequence F description BINDING SITE FOR RESIDUE K A 503 source : AC3 17) chain A residue 181 type sequence F description BINDING SITE FOR RESIDUE K A 504 source : AC4 18) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE K A 504 source : AC4 19) chain A residue 187 type sequence V description BINDING SITE FOR RESIDUE K A 504 source : AC4 20) chain A residue 217 type sequence Y description BINDING SITE FOR RESIDUE K A 504 source : AC4 21) chain A residue 113 type sequence Q description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 22) chain A residue 116 type sequence T description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 23) chain B residue 265 type sequence R description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 24) chain A residue 116 type sequence T description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 25) chain A residue 119 type sequence N description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 26) chain A residue 120 type sequence N description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 27) chain A residue 156 type sequence E description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 28) chain A residue 160 type sequence Y description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 29) chain D residue 449 type sequence K description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 30) chain B residue 170 type sequence D description BINDING SITE FOR RESIDUE ZN B 500 source : AC7 31) chain B residue 172 type sequence H description BINDING SITE FOR RESIDUE ZN B 500 source : AC7 32) chain B residue 259 type sequence D description BINDING SITE FOR RESIDUE ZN B 500 source : AC7 33) chain B residue 134 type sequence H description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 34) chain B residue 135 type sequence H description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 35) chain B residue 170 type sequence D description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 36) chain B residue 172 type sequence H description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 37) chain B residue 259 type sequence D description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 38) chain B residue 296 type sequence G description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 39) chain B residue 298 type sequence Y description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 40) chain C residue 412 type sequence M description BINDING SITE FOR RESIDUE ACT B 501 source : AC8 41) chain B residue 168 type sequence D description BINDING SITE FOR RESIDUE K B 503 source : AC9 42) chain B residue 170 type sequence D description BINDING SITE FOR RESIDUE K B 503 source : AC9 43) chain B residue 172 type sequence H description BINDING SITE FOR RESIDUE K B 503 source : AC9 44) chain B residue 191 type sequence S description BINDING SITE FOR RESIDUE K B 503 source : AC9 45) chain B residue 192 type sequence F description BINDING SITE FOR RESIDUE K B 503 source : AC9 46) chain B residue 181 type sequence F description BINDING SITE FOR RESIDUE K B 504 source : BC1 47) chain B residue 184 type sequence T description BINDING SITE FOR RESIDUE K B 504 source : BC1 48) chain B residue 187 type sequence V description BINDING SITE FOR RESIDUE K B 504 source : BC1 49) chain B residue 217 type sequence Y description BINDING SITE FOR RESIDUE K B 504 source : BC1 50) chain A residue 265 type sequence R description BINDING SITE FOR RESIDUE GOL B 505 source : BC2 51) chain B residue 51 type sequence Y description BINDING SITE FOR RESIDUE GOL B 505 source : BC2 52) chain B residue 113 type sequence Q description BINDING SITE FOR RESIDUE GOL B 505 source : BC2 53) chain B residue 116 type sequence T description BINDING SITE FOR RESIDUE GOL B 505 source : BC2 54) chain B residue 119 type sequence N description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 55) chain B residue 120 type sequence N description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 56) chain B residue 156 type sequence E description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 57) chain B residue 160 type sequence Y description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 58) chain C residue 449 type sequence K description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 59) chain C residue 470 type sequence Y description BINDING SITE FOR RESIDUE GOL B 506 source : BC3 60) chain A residue 17 type sequence H description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 61) chain A residue 21 type sequence G description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 62) chain A residue 25 type sequence K description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 63) chain A residue 265 type sequence R description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 64) chain A residue 300 type sequence V description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 65) chain A residue 301 type sequence R description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 66) chain A residue 331 type sequence Y description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 67) chain B residue 120 type sequence N description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 68) chain C residue 449 type sequence K description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 69) chain C residue 470 type sequence Y description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 70) chain C residue 471 type sequence Y description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 71) chain C residue 474 type sequence K description BINDING SITE FOR RESIDUE I0P C 501 source : BC4 72) chain A residue 116 type sequence T description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 73) chain A residue 120 type sequence N description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 74) chain B residue 17 type sequence H description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 75) chain B residue 21 type sequence G description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 76) chain B residue 22 type sequence H description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 77) chain B residue 25 type sequence K description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 78) chain B residue 265 type sequence R description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 79) chain B residue 300 type sequence V description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 80) chain B residue 331 type sequence Y description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 81) chain D residue 449 type sequence K description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 82) chain D residue 470 type sequence Y description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 83) chain D residue 471 type sequence Y description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 84) chain D residue 474 type sequence K description BINDING SITE FOR RESIDUE I0P D 501 source : BC5 85) chain B residue 135 type ACT_SITE sequence H description ACT_SITE => ECO:0000250|UniProtKB:Q13547 source Swiss-Prot : SWS_FT_FI1 86) chain A residue 135 type ACT_SITE sequence H description ACT_SITE => ECO:0000250|UniProtKB:Q13547 source Swiss-Prot : SWS_FT_FI1

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