eF-site ID 4a5w-AB PDB Code 4a5w Chain A, B click to enlarge Title Crystal structure of C5b6 Classification IMMUNE SYSTEM Compound COMPLEMENT C5 Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence A:  TYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPD KKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSY VYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSV KVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIG IISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKE YVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVT EADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTF DSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAE IPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQ LVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFV LNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLS QSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNY LILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLL VYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADA YSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLE RVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADD SQENDEPCKEIRSYFPESWLWEVHLVPRRKQLQFALPDSL TTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVV RGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVID HQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSL ETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTIS RRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQ EGINILTHAEAELMSVVPVFYVFHYLETGNHWNIFHSDPL IEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLT AFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFK ENSQLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTAL IKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSI VSALKREALVKGNPPIYRFWKDNLQHGTARMVETTAYALL TSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEG LTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGR PVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCS FYLKIDTQDIYKRIVACASYKPSREESSSGSSHAVMDISL PTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIP SSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMF YSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETR KQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTG EAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIK YNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFA EDIFLNGC B:  CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFC EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQS KVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCK NKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSL QGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSF IRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSAL YSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTE EEAKHCVRIETHRCTTNKLSEKHEGSFIQGAEKSISLIRG GEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTK RNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVC QSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKR SRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPC INDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYL VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR YTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSE CICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKC LNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCG YDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSS TSEKTLNICEVGTIRCANRKMEILHPGKCLA Description Functional site 1) chain B residue 541-552 type prosite sequence CVCQSGTYGENC description EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC source prosite : PS00022 2) chain B residue 354-365 type prosite sequence YSRIFDDFGTHY description MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY source prosite : PS00279 3) chain B residue 151-173 type prosite sequence CIARKLECNGENDCGDNSDERDC description LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C source prosite : PS01209 4) chain B residue 855 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI5 5) chain B residue 29 type CARBOHYD sequence W description C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 32 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 90 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 568 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 571 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 574 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 38 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 12) chain B residue 392 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 324 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22267737 source Swiss-Prot : SWS_FT_FI4

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