eF-site ID 4a51-CDEFG PDB Code 4a51 Chain C, D, E, F, G click to enlarge Title Crystal structure of human kinesin Eg5 in complex with 1-(3-(((2-Aminoethyl)thio)diphenylmethyl)phenyl)ethanone hydrochloride Classification CELL CYCLE Compound KINESIN-LIKE PROTEIN KIF11 Source Homo sapiens (Human) (KIF11_HUMAN) Sequence C:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDL AGSENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQ DSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILN KPEVN D:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKEELVKIGKLNL VDLAGSENINQSLLTLGRVITALVERTPHVPYRESKLTRI LQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNI LN E:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDL AGSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQD SLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNK P F:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHKIGKLNLVDLAGS ENNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSL GGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP G:  NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGL ADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGY NCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIP RTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSD VSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG AAKRTTAATLMNAYSSRSHSVFSVTIHMKIGKLNLVDLAG SENNQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLG GRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKP Description Functional site 1) chain C residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 2) chain C residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 3) chain C residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 4) chain C residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 5) chain C residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 6) chain C residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 7) chain C residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 8) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 9) chain C residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 10) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 11) chain G residue 226 type sequence T description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 12) chain G residue 227 type sequence L description BINDING SITE FOR RESIDUE ADP C 601 source : AC7 13) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE MG C 701 source : AC8 14) chain C residue 112 type sequence T description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 15) chain C residue 116 type sequence E description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 16) chain C residue 117 type sequence G description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 17) chain C residue 118 type sequence E description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 18) chain C residue 119 type sequence R description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 19) chain C residue 136 type sequence I description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 20) chain C residue 137 type sequence P description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 21) chain C residue 160 type sequence L description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 22) chain C residue 211 type sequence Y description BINDING SITE FOR RESIDUE DQ8 C 801 source : AC9 23) chain D residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 24) chain D residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 25) chain D residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 26) chain D residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 27) chain D residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 28) chain D residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 29) chain D residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 30) chain D residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 31) chain D residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 32) chain D residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP D 601 source : BC1 33) chain D residue 112 type sequence T description BINDING SITE FOR RESIDUE MG D 701 source : BC2 34) chain D residue 265 type sequence D description BINDING SITE FOR RESIDUE MG D 701 source : BC2 35) chain D residue 116 type sequence E description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 36) chain D residue 117 type sequence G description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 37) chain D residue 118 type sequence E description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 38) chain D residue 136 type sequence I description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 39) chain D residue 137 type sequence P description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 40) chain D residue 160 type sequence L description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 41) chain D residue 211 type sequence Y description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 42) chain D residue 214 type sequence L description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 43) chain D residue 218 type sequence A description BINDING SITE FOR RESIDUE DQ8 D 801 source : BC3 44) chain E residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 45) chain E residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 46) chain E residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 47) chain E residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 48) chain E residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 49) chain E residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 50) chain E residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 51) chain E residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 52) chain E residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 53) chain E residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP E 601 source : BC4 54) chain E residue 112 type sequence T description BINDING SITE FOR RESIDUE MG E 701 source : BC5 55) chain E residue 116 type sequence E description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 56) chain E residue 117 type sequence G description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 57) chain E residue 118 type sequence E description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 58) chain E residue 119 type sequence R description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 59) chain E residue 133 type sequence A description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 60) chain E residue 137 type sequence P description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 61) chain E residue 160 type sequence L description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 62) chain E residue 211 type sequence Y description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 63) chain E residue 214 type sequence L description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 64) chain E residue 215 type sequence E description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 65) chain E residue 218 type sequence A description BINDING SITE FOR RESIDUE DQ8 E 801 source : BC6 66) chain F residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 67) chain F residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 68) chain F residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 69) chain F residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 70) chain F residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 71) chain F residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 72) chain F residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 73) chain F residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 74) chain F residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP F 601 source : BC7 75) chain F residue 112 type sequence T description BINDING SITE FOR RESIDUE MG F 701 source : BC8 76) chain F residue 117 type sequence G description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 77) chain F residue 118 type sequence E description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 78) chain F residue 119 type sequence R description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 79) chain F residue 136 type sequence I description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 80) chain F residue 137 type sequence P description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 81) chain F residue 160 type sequence L description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 82) chain F residue 211 type sequence Y description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 83) chain F residue 214 type sequence L description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 84) chain F residue 215 type sequence E description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 85) chain F residue 218 type sequence A description BINDING SITE FOR RESIDUE DQ8 F 801 source : BC9 86) chain G residue 24 type sequence R description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 87) chain G residue 26 type sequence R description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 88) chain G residue 27 type sequence P description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 89) chain G residue 106 type sequence Q description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 90) chain G residue 107 type sequence T description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 91) chain G residue 108 type sequence G description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 92) chain G residue 109 type sequence T description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 93) chain G residue 110 type sequence G description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 94) chain G residue 111 type sequence K description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 95) chain G residue 112 type sequence T description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 96) chain G residue 113 type sequence F description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 97) chain G residue 118 type sequence E description BINDING SITE FOR RESIDUE ADP G 601 source : CC1 98) chain G residue 112 type sequence T description BINDING SITE FOR RESIDUE MG G 701 source : CC2 99) chain C residue 124 type sequence E description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 100) chain C residue 125 type sequence Y description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 101) chain G residue 116 type sequence E description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 102) chain G residue 117 type sequence G description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 103) chain G residue 137 type sequence P description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 104) chain G residue 160 type sequence L description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 105) chain G residue 211 type sequence Y description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 106) chain G residue 214 type sequence L description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 107) chain G residue 215 type sequence E description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 108) chain G residue 218 type sequence A description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 109) chain G residue 221 type sequence R description BINDING SITE FOR RESIDUE DQ8 G 801 source : CC3 110) chain C residue 47 type sequence R description BINDING SITE FOR RESIDUE SO4 D 1362 source : CC4 111) chain D residue 42 type sequence E description BINDING SITE FOR RESIDUE SO4 D 1362 source : CC4 112) chain D residue 43 type sequence C description BINDING SITE FOR RESIDUE SO4 D 1362 source : CC4 113) chain D residue 74 type sequence A description BINDING SITE FOR RESIDUE SO4 D 1362 source : CC4 114) chain C residue 43 type sequence C description BINDING SITE FOR RESIDUE CL C 1367 source : DC1 115) chain C residue 354 type sequence H description BINDING SITE FOR RESIDUE CL C 1369 source : DC3 116) chain D residue 186 type sequence D description BINDING SITE FOR RESIDUE CL D 1363 source : DC4 117) chain D residue 318 type sequence R description BINDING SITE FOR RESIDUE CL D 1363 source : DC4 118) chain D residue 30 type sequence L description BINDING SITE FOR RESIDUE CL D 1364 source : DC5 119) chain E residue 43 type sequence C description BINDING SITE FOR RESIDUE CL E 1364 source : DC6 120) chain E residue 73 type sequence G description BINDING SITE FOR RESIDUE CL E 1364 source : DC6 121) chain G residue 229 type sequence N description BINDING SITE FOR RESIDUE CL G 1364 source : DC7 122) chain C residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 123) chain D residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 124) chain E residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 125) chain F residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 126) chain G residue 105 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00283 source Swiss-Prot : SWS_FT_FI1 127) chain C residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 128) chain D residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 129) chain E residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 130) chain F residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 131) chain G residue 146 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2

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