eF-site ID 4a4c-ABC PDB Code 4a4c Chain A, B, C click to enlarge Title Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex Classification LIGASE/TRANSFERASE Compound E3 UBIQUITIN-PROTEIN LIGASE CBL Source (UB2D2_HUMAN) Sequence A:  PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDL LPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTK QTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKG IFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQ ALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRL FQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHK PGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQA LIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQ YELXCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTS WQESEGQGCPFCRCEIKGTEPIVVDPFD B:  SDGXTPEPA C:  ALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPN DSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSN GSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVP EIARIYKDREKYNRIAREWTQKYAM Description Functional site 1) chain A residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 2) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 3) chain A residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 4) chain A residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 5) chain A residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 6) chain A residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 7) chain A residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 8) chain A residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 9) chain A residue 229 type sequence D description BINDING SITE FOR RESIDUE CA A 1438 source : AC3 10) chain A residue 231 type sequence T description BINDING SITE FOR RESIDUE CA A 1438 source : AC3 11) chain A residue 233 type sequence N description BINDING SITE FOR RESIDUE CA A 1438 source : AC3 12) chain A residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA A 1438 source : AC3 13) chain A residue 240 type sequence E description BINDING SITE FOR RESIDUE CA A 1438 source : AC3 14) chain A residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 85 type ACT_SITE sequence C description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 7 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 231 type MOD_RES sequence T description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 233 type MOD_RES sequence N description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 235 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 240 type MOD_RES sequence E description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 371 type MOD_RES sequence X description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 396-405 type prosite sequence CGHLMCTSCL description ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL source prosite : PS00518 23) chain C residue 74-89 type prosite sequence YHPNINSNGSICLDIL description UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL source prosite : PS00183

Display surface Download Links