eF-site ID 4a3q-AB PDB Code 4a3q Chain A, B click to enlarge Title The 2.15 Angstrom resolution crystal structure of Staphylococcus aureus alanine racemase Classification ISOMERASE Compound ALANINE RACEMASE 1 Source null (ALR1_STAAM) Sequence A:  SDKYYRSAYMNVDLNAVASNFKVFSTLHPNKTVMAVVKAN AYGLGSVKVARHLMENGATFFAVATLDEAIELRMHGITAK ILVLGVLPAKDIDKAIQHRVALTVPSKQWLKEAIKNISGE QEKKLWLHIKLDTGMGRLGIKDTNTYQEVIEIIQQYEQLV FEGVFTHFDMTTEQYQRFKDMVNEAIKPEYIHCQNSAGSL LMDCQFCNAIRPGISLYGYYPSEYVQQKVKVHLKPSVQLI ANVVQTKTTTIALLPIGYADGYLRIMQGSFVNVNGHQCEV IGRVCMDQTIVKVPDQVKAGDSVILIDNHRESPQSVEVVA EKQHTINYEVLCNLSRRLPRIYHDGDQRFVTNELLK B:  SDKYYRSAYMNVDLNAVASNFKVFSTLHPNKTVMAVVKAN AYGLGSVKVARHLMENGATFFAVATLDEAIELRMHGITAK ILVLGVLPAKDIDKAIQHRVALTVPSKQWLKEAIKNISGE QEKKLWLHIKLDTGMGRLGIKDTNTYQEVIEIIQQYEQLV FEGVFTHFTTEQYQRFKDMVNEAIKPEYIHCQNSAGSLLM DCQFCNAIRPGISLYGYYPSEYVQQKVKVHLKPSVQLIAN VVQTKTLPTTIALLPIGYADGYLRIMQGSFVNVNGHQCEV IGRVCMDQTIVKVPDQVKAGDSVILIDNHRESPQSVEVVA EKQHTINYEVLCNLSRRLPRIYHDGDQRFVTNELLK Description Functional site 1) chain A residue 39 type sequence K description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 2) chain A residue 43 type sequence Y description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 3) chain A residue 168 type sequence H description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 4) chain A residue 203 type sequence N description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 5) chain A residue 204 type sequence S description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 6) chain A residue 219 type sequence R description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 7) chain A residue 221 type sequence G description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 8) chain A residue 222 type sequence I description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 9) chain A residue 354 type sequence Y description BINDING SITE FOR RESIDUE PLP A 1039 source : AC1 10) chain A residue 228 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1383 source : AC2 11) chain A residue 234 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1383 source : AC2 12) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1383 source : AC2 13) chain A residue 241 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1383 source : AC2 14) chain A residue 336 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1383 source : AC2 15) chain A residue 107 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1384 source : AC3 16) chain A residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1384 source : AC3 17) chain A residue 109 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1384 source : AC3 18) chain A residue 146 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1384 source : AC3 19) chain A residue 48 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1385 source : AC4 20) chain A residue 49 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1385 source : AC4 21) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1385 source : AC4 22) chain A residue 76 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1385 source : AC4 23) chain A residue 335 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1386 source : AC5 24) chain A residue 336 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1386 source : AC5 25) chain A residue 337 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1386 source : AC5 26) chain A residue 29 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1387 source : AC6 27) chain A residue 30 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1387 source : AC6 28) chain A residue 31 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1387 source : AC6 29) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1387 source : AC6 30) chain A residue 131 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1388 source : AC7 31) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1388 source : AC7 32) chain A residue 139 type sequence L description BINDING SITE FOR RESIDUE SO4 A 1388 source : AC7 33) chain A residue 168 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1388 source : AC7 34) chain B residue 314 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1388 source : AC7 35) chain A residue 311 type sequence C description BINDING SITE FOR RESIDUE ACT A 1389 source : AC8 36) chain A residue 312 type sequence M description BINDING SITE FOR RESIDUE ACT A 1389 source : AC8 37) chain B residue 39 type sequence K description BINDING SITE FOR RESIDUE ACT A 1389 source : AC8 38) chain B residue 39 type sequence K description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 39) chain B residue 43 type sequence Y description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 40) chain B residue 168 type sequence H description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 41) chain B residue 204 type sequence S description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 42) chain B residue 219 type sequence R description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 43) chain B residue 221 type sequence G description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 44) chain B residue 222 type sequence I description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 45) chain B residue 354 type sequence Y description BINDING SITE FOR RESIDUE PLP B 1039 source : AC9 46) chain B residue 228 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 1383 source : BC1 47) chain B residue 234 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1383 source : BC1 48) chain B residue 240 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1383 source : BC1 49) chain B residue 241 type sequence L description BINDING SITE FOR RESIDUE SO4 B 1383 source : BC1 50) chain B residue 336 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1383 source : BC1 51) chain B residue 49 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1384 source : BC2 52) chain B residue 52 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1384 source : BC2 53) chain B residue 76 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1384 source : BC2 54) chain A residue 361 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1385 source : BC3 55) chain A residue 362 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1385 source : BC3 56) chain B residue 360 type sequence L description BINDING SITE FOR RESIDUE SO4 B 1385 source : BC3 57) chain B residue 361 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1385 source : BC3 58) chain B residue 362 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1385 source : BC3 59) chain B residue 107 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1386 source : BC4 60) chain B residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1386 source : BC4 61) chain B residue 109 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1386 source : BC4 62) chain B residue 335 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1387 source : BC5 63) chain B residue 336 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1387 source : BC5 64) chain B residue 337 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1387 source : BC5 65) chain A residue 108 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 66) chain A residue 112 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 67) chain B residue 29 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 68) chain B residue 30 type sequence P description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 69) chain B residue 31 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 70) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 71) chain B residue 211 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 72) chain B residue 213 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1388 source : BC6 73) chain B residue 131 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1389 source : BC7 74) chain B residue 138 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1389 source : BC7 75) chain B residue 139 type sequence L description BINDING SITE FOR RESIDUE SO4 B 1389 source : BC7 76) chain B residue 168 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1389 source : BC7 77) chain A residue 39 type sequence K description BINDING SITE FOR RESIDUE ACT B 1390 source : BC8 78) chain A residue 354 type sequence Y description BINDING SITE FOR RESIDUE ACT B 1390 source : BC8 79) chain B residue 284 type sequence Y description BINDING SITE FOR RESIDUE ACT B 1390 source : BC8 80) chain B residue 311 type sequence C description BINDING SITE FOR RESIDUE ACT B 1390 source : BC8 81) chain B residue 312 type sequence M description BINDING SITE FOR RESIDUE ACT B 1390 source : BC8 82) chain B residue 39 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000305|PubMed:22194336 source Swiss-Prot : SWS_FT_FI1 83) chain A residue 39 type ACT_SITE sequence K description Proton acceptor; specific for D-alanine => ECO:0000305|PubMed:22194336 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 138 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI3 85) chain A residue 138 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_01201 source Swiss-Prot : SWS_FT_FI3 86) chain B residue 312 type BINDING sequence M description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI4 87) chain A residue 312 type BINDING sequence M description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI4 88) chain A residue 36-46 type prosite sequence AVVKANAYGLG description ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGLG source prosite : PS00395 89) chain A residue 39 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI5 90) chain B residue 39 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI5

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