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eF-site ID
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4a3l-A |
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PDB Code
|
4a3l |
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Chain
|
A |
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click to enlarge
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Title
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RNA Polymerase II initial transcribing complex with a 7nt DNA-RNA hybrid and soaked with AMPCPP |
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Classification
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TRANSCRIPTION |
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Compound
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DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 |
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Source
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ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; |
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Sequence
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A: |
GQQYSSAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMD
ETQTRAKIGGLNDPRLGSIDRNLKCQTCQEGMNECPGHFG
HIDLAKPVFHVGFIAKIKKVCECVCMHCGKLLLDEHNELM
RQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDDPTQLV
SRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVL
STEEILNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVP
PPPVRPSISFNESQRGEDDLTFKLADILKANISLETLEHN
GAPHHAIEEAESLLQFHVATYMDNDIAGQPQALQKSGRPV
KSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDPNLELD
QVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGA
KYVIRDSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPV
LFNRQPSLHKMSMMAHRVKVIPYSTFRLNLSVTSPYNADF
DGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPCMG
IVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWDGVIPT
PAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKD
NGMLIIDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVC
AKLFGNIQKVVNFWLLHNGFSTGIGDTIADGPTMREITET
IAEAKKKVLDVTKEAQANLLTAKHGMTLRESFEDNVVRFL
NEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFINIAQMS
ACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVEN
SYLRGLTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLV
KALEDIMVHYDNTTRNSLGNVIQFIYGEDGMDAAHIEKQS
LDTIGGSDAAFEKRYRVDLLNTDHTLDPSLLESGSEILGD
LKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLPVNIRR
IIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRG
KNEIIQNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAF
DWVLSNIEAQFLRSVVHPGEMVGVLAAQSIGEPATQMTLN
TKKVTSGVPRLKEILNVAKNMKTPSLTVYLEPGHAADQEQ
AKLIRSAIEHTTLKSVTIASEIYYDPDPRSTVIPEDEEII
QLHFSLQQSPWLLRLELDRAAMNDKDLTMGQVGERIKQTF
KNDLFVIWSEDNDEKLIIRCRVVAEEDHMLKKIENTMLEN
ITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLETDG
VNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYK
EVYNVIASDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFN
RSNTGALMRCSFEETVEILFEAGASAELDDCRGVSENVIL
GQMAPIGTGAFDVMIDEESLVKYMP
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Description
|
(1) |
DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4
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Functional site
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1)
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chain |
A |
| residue |
107 |
| type |
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| sequence |
C
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| description |
BINDING SITE FOR RESIDUE ZN A 2456
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| source |
: AC1
|
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2)
|
chain |
A |
| residue |
110 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2456
|
| source |
: AC1
|
|
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3)
|
chain |
A |
| residue |
148 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2456
|
| source |
: AC1
|
|
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4)
|
chain |
A |
| residue |
167 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2456
|
| source |
: AC1
|
|
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5)
|
chain |
A |
| residue |
67 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2457
|
| source |
: AC2
|
|
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6)
|
chain |
A |
| residue |
70 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2457
|
| source |
: AC2
|
|
|
7)
|
chain |
A |
| residue |
77 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE ZN A 2457
|
| source |
: AC2
|
|
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8)
|
chain |
A |
| residue |
80 |
| type |
|
| sequence |
H
|
| description |
BINDING SITE FOR RESIDUE ZN A 2457
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| source |
: AC2
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|
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9)
|
chain |
A |
| residue |
481 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG A 2458
|
| source |
: AC3
|
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10)
|
chain |
A |
| residue |
483 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG A 2458
|
| source |
: AC3
|
|
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11)
|
chain |
A |
| residue |
485 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG A 2458
|
| source |
: AC3
|
|
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12)
|
chain |
A |
| residue |
446 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE APC P 1011
|
| source |
: BC1
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|
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13)
|
chain |
A |
| residue |
448 |
| type |
|
| sequence |
P
|
| description |
BINDING SITE FOR RESIDUE APC P 1011
|
| source |
: BC1
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14)
|
chain |
A |
| residue |
479 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE APC P 1011
|
| source |
: BC1
|
|
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15)
|
chain |
A |
| residue |
481 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE APC P 1011
|
| source |
: BC1
|
|
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16)
|
chain |
A |
| residue |
1082 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE APC P 1011
|
| source |
: BC1
|
|
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17)
|
chain |
A |
| residue |
483 |
| type |
catalytic |
| sequence |
D
|
| description |
788
|
| source |
MCSA : MCSA1
|
|
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18)
|
chain |
A |
| residue |
485 |
| type |
catalytic |
| sequence |
D
|
| description |
788
|
| source |
MCSA : MCSA1
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|
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19)
|
chain |
A |
| residue |
483 |
| type |
ZN_FING |
| sequence |
D
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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20)
|
chain |
A |
| residue |
485 |
| type |
ZN_FING |
| sequence |
D
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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21)
|
chain |
A |
| residue |
107 |
| type |
ZN_FING |
| sequence |
C
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
22)
|
chain |
A |
| residue |
110 |
| type |
ZN_FING |
| sequence |
C
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
23)
|
chain |
A |
| residue |
148 |
| type |
ZN_FING |
| sequence |
C
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
24)
|
chain |
A |
| residue |
167 |
| type |
ZN_FING |
| sequence |
C
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
25)
|
chain |
A |
| residue |
481 |
| type |
ZN_FING |
| sequence |
D
|
| description |
C4-type
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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