eF-site ID 4a3f-B PDB Code 4a3f Chain B click to enlarge Title RNA Polymerase II initial transcribing complex with a 6nt DNA-RNA hybrid and soaked with AMPCPP Classification TRANSCRIPTION Compound DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 Source ORGANISM_COMMON: BAKER'S YEAST; ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE; Sequence B:  DESAPITAEDSWAVISAFFREKGLVSQQLDSFNQFVDYTL QDIICEDSTLIISFGKIYVTKPMVNESDGVTHALYPQEAR LRNLTYSSGLFVDVKKKVFIGRLPIMLRSKNCYLSEATES DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFK KAAPSPISHVAEIRSALEKGSRFISTLQVKLYGREGSSAR TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVND WQMLEMLKPCVEDGFVIQDRETALDFIGRRGTALGIKKEK RIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLL CALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKD IFRYMQRTVELAINAKTITSGLKYALATGNWGEQKKAMSS RAGVSQVLNRYTYSSTLSHLRRTNTPIAKPRQLHNTHWGL VCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEW GMEPLEDYVPHQSPDATRVFVNGVWHGVHRNPARLMETLR TLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVE DDESLGHKELKVRKGHIAKLMATEYQDEYTWSSLLNEGLV EYIDAEEEESILIAMQPEDLEPAEADVDPAKRIRVSHHAT TFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQ AMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRE LPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFF RSYMDQEKKYGMSITETFEKPQRTNTLRMKHGTYDKLDDD GLIAPGVRVSGEDVIIGKTTPISSKRDASTPLRSTENGIV DQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGT IGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIEC LLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGF EVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARG PMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKE RLMEASDAFRVHICGICGLMTVIAKLNHNQFECKGCDNKI DIYQIHIPYAAKLLFQELMAMNITPRLYTDRSRDF Description (1)  DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (E.C.2.7.7.6), DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2, RPB7, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 Functional site 1) chain B residue 529 type sequence E description BINDING SITE FOR RESIDUE APC A 2455 source : AC1 2) chain B residue 766 type sequence R description BINDING SITE FOR RESIDUE APC A 2455 source : AC1 3) chain B residue 1020 type sequence R description BINDING SITE FOR RESIDUE APC A 2455 source : AC1 4) chain B residue 1163 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC5 5) chain B residue 1166 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC5 6) chain B residue 1182 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC5 7) chain B residue 1185 type sequence C description BINDING SITE FOR RESIDUE ZN B 2225 source : AC5 8) chain B residue 977-989 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166 9) chain B residue 837 type catalytic sequence D description 788 source MCSA : MCSA1 10) chain B residue 1185 type BINDING sequence C description source Swiss-Prot : SWS_FT_FI2

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