eF-site ID 3zzw-B PDB Code 3zzw Chain B click to enlarge Title Crystal structure of the kinase domain of ROR2 Classification TRANSFERASE Compound TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2 Source Homo sapiens (Human) (ROR2_HUMAN) Sequence B:  KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVA IKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTK DQPLSMIFSYCSHGDLHEFLVMRSPDFVHLVAQIAAGMEY LSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADY YKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEV FSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALM IECWNEFPSRRPRFKDIHSRLRAWG Description Functional site 1) chain B residue 594 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 2) chain B residue 597 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 3) chain B residue 598 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 4) chain B residue 743 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 5) chain B residue 747 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 6) chain B residue 638 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 7) chain B residue 639 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 8) chain B residue 640 type sequence V description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 9) chain B residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 13) chain B residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4

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