eF-site ID 3zzw-AB PDB Code 3zzw Chain A, B click to enlarge Title Crystal structure of the kinase domain of ROR2 Classification TRANSFERASE Compound TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2 Source Homo sapiens (Human) (ROR2_HUMAN) Sequence A:  KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVA IKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTK DQPLSMIFSYCSHGDLHEFLVMRSALEPPDFVHLVAQIAA GMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY AADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVV LWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWV YALMIECWNEFPSRRPRFKDIHSRLRAWG B:  KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVA IKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTK DQPLSMIFSYCSHGDLHEFLVMRSPDFVHLVAQIAAGMEY LSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADY YKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEV FSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALM IECWNEFPSRRPRFKDIHSRLRAWG Description Functional site 1) chain A residue 558 type sequence H description BINDING SITE FOR RESIDUE CL A 1751 source : AC1 2) chain A residue 624 type sequence Y description BINDING SITE FOR RESIDUE CL A 1751 source : AC1 3) chain A residue 627 type sequence L description BINDING SITE FOR RESIDUE CL A 1751 source : AC1 4) chain A residue 665 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1752 source : AC2 5) chain A residue 666 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1752 source : AC2 6) chain A residue 706 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1752 source : AC2 7) chain A residue 697 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1753 source : AC3 8) chain A residue 698 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1753 source : AC3 9) chain A residue 699 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1753 source : AC3 10) chain B residue 594 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 11) chain B residue 597 type sequence A description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 12) chain B residue 598 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 13) chain B residue 743 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 14) chain B residue 747 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1751 source : AC4 15) chain B residue 638 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 16) chain B residue 639 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 17) chain B residue 640 type sequence V description BINDING SITE FOR RESIDUE SO4 B 1752 source : AC5 18) chain A residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 615 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 479 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 507 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 469 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 471 type MOD_RES sequence S description Sulfoserine; partial => ECO:0000269|PubMed:14752058 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 646 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 611-623 type prosite sequence VVHKDLATRNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. VVHkDLATRNVLV source prosite : PS00109

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