eF-site ID 3znz-AB PDB Code 3znz Chain A, B click to enlarge Title Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin Classification HYDROLASE Compound PROTEIN FAM105B Source null (F5H265_HUMAN) Sequence A:  GPLSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKF TSIRRVRGDNYAALRATLFQAMSQAVGLPPWLQDPELMLL PEKLISKYNWIKQWKLGDLVDKIKESLTLLRKKWAGLAEM RTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAIELYN DKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGG LEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPPK DWPVVTLIAEDDRHYNIPVRVCEETS B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIF VKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLI FAGKQLEDGRTLSDYNIQKESTLHLV Description Functional site 1) chain A residue 271 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 2) chain A residue 274 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 3) chain A residue 275 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 4) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC2 5) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC3 6) chain A residue 207 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC3 7) chain B residue 85 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC3 8) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC4 9) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC4 10) chain A residue 281 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1356 source : AC5 11) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1356 source : AC5 12) chain B residue 139 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1356 source : AC5 13) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 14) chain A residue 265 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 15) chain B residue 42 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 16) chain B residue 49 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 17) chain B residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 18) chain B residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 19) chain B residue 133 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1148 source : AC7 20) chain A residue 126 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI1 21) chain A residue 339 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI1 22) chain A residue 129 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:24726327, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI2 23) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 24) chain B residue 103-128 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 25) chain A residue 314 type SITE sequence E description Linear diubiquitin binding => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSK, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI3

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