eF-site ID 3znz-A PDB Code 3znz Chain A click to enlarge Title Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin Classification HYDROLASE Compound PROTEIN FAM105B Source null (F5H265_HUMAN) Sequence A:  GPLSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKF TSIRRVRGDNYAALRATLFQAMSQAVGLPPWLQDPELMLL PEKLISKYNWIKQWKLGDLVDKIKESLTLLRKKWAGLAEM RTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAIELYN DKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGG LEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPPK DWPVVTLIAEDDRHYNIPVRVCEETS Description Functional site 1) chain A residue 271 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 2) chain A residue 274 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 3) chain A residue 275 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1352 source : AC1 4) chain A residue 299 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1353 source : AC2 5) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC3 6) chain A residue 207 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1354 source : AC3 7) chain A residue 338 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1355 source : AC4 8) chain A residue 281 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1356 source : AC5 9) chain A residue 282 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1356 source : AC5 10) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 11) chain A residue 265 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1147 source : AC6 12) chain A residue 126 type ACT_SITE sequence D description ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI1 13) chain A residue 339 type ACT_SITE sequence H description ACT_SITE => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI1 14) chain A residue 129 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0000269|PubMed:24726327, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI2 15) chain A residue 314 type SITE sequence E description Linear diubiquitin binding => ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:23746843, ECO:0007744|PDB:3ZNZ, ECO:0007744|PDB:4KSK, ECO:0007744|PDB:4KSL source Swiss-Prot : SWS_FT_FI3

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